布地奈德混悬液联合泛福舒对哮喘预测指标阳性喘息患儿肺功能的影响  

Effect of budesonide suspension combined with broncho-vaxom on lung function in children with API positive wheezing

作　　者：李奕 沈照波 张婕[3] 康平 翟璐璐 Li Yi;Shen Zhaobo;Zhang Jie;Kang Ping;Zhai Lulu(Zhengzhou Key Laboratory of Children's Respiratory Diseases/Allergy Room,Children's Hospital Affiliated to Zhengzhou University(Henan Children's Hospital,Zhengzhou Children's Hospital),Zhengzhou 450000,China;Department of Respiratory Medicine,Children's Hospital Affiliated to Zhengzhou University(Henan Children's Hospital,Zhengzhou Children's Hospital),Zhengzhou 450000,China;Scientific Research Office,Children's Hospital Affiliated to Zhengzhou University(Henan Children's Hospital,Zhengzhou Children's Hospital),Zhengzhou 450000,China)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院郑州市儿童呼吸疾病重点实验室/变态反应室,450000 [2]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院呼吸内科,450000 [3]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院科研办,450000

出　　处：《国际医药卫生导报》2020年第24期3732-3734,共3页International Medicine and Health Guidance News

基　　金：2019年度河南省医学科技攻关计划项目(HLGJ20190907);2014年度河南省医学科技攻关计划项目(201403252)。

摘　　要：目的布地奈德混悬液联合泛福舒对哮喘预测指标阳性喘息患儿肺功能的影响。方法随机选取2017年5月至2019年5月本院收治的132喘息患儿为研究对象,患儿喘息预测指标均为阳性,根据年龄分层分为观察组与对照组。对照组给予布地奈德悬浮液治疗,观察组加用泛福舒,共治疗2周,疗程结束后比较两组肺功能变化,评估治疗效果。结果治疗后,观察组TPTEF/TE、VPEF/VE分别是(28.4±3.5)、(27.4±4.5),均显著高于对照组的(26.6±3.7)、(25.8±4.3),差异均具有统计学意义(均P<0.05)。治疗后两组均无无效病例,观察组临床控制49例,显效15例,好转2例,治疗效果显著优于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率3.03%,对照组1.52%,差异无统计学意义(P>0.05)。结论布地奈德混悬液联合泛福舒可显著改善哮喘预测指标阳性喘息患儿的肺功能,且安全性较高,有助于患儿恢复健康。Objective To analyze the effect of budesonide suspension combined with broncho-vaxom on lung function of children with asthma predictive index(API)positive wheezing.Methods From May,2017 to May,2019,132 children with wheezing treated at our hospital were randomly selected as the research objects;the predictive indicators of children's wheezing were positive.The children were divided into an observation group and a control group according to their age stratification.The control group was treated with budesonide suspension,and the observation group was additionally given broncho-vaxom,for 2 weeks.After the end of the treatment,the lung function changes were compared and the treatment effects were evaluated.Results After the treatment, the TPTEF/TE and VPEF/VE of the observation group were significantly higher thanthose of the control group [(28.4±3.5) vs. (26.6±3.7) and (27.4±4.5) vs. (25.8±4.3);both P<0.05].After the treatment, there were no invalid cases in both groups. There were 49 clinically controlledcases, 15 markedly effective cases, and 2 improved cases in the observation group;and the treatmenteffect was significantly better in the observation than in the control group (P<0.05). There was nostatistical difference in the incidence of adverse reactions between the observation group and thecontrol group (3.03% vs. 1.52%;P>0.05). Conclusion Budesonide suspension combined withbroncho-vaxom can significantly improve the lung function of children with API positive wheezing,and has high safety and can help promote the children's health recovery.

关 键 词：布地奈德 泛福舒 哮喘 肺功能 

分 类 号：R725.6[医药卫生—儿科]