Yanangdaengin,a dihydrochalcone glucoside galloyl ester as active antioxidative agent from leaves of Lysiphyllum strychnifolium(syn.Bauhinia strychnifolia)  

作　　者：Sumet Kongkiatpaiboon Nongnaphat Duangdee Ngampuk Tayana Johann Schinnerl Markus Bacher Savita Chewchinda 

机构地区：[1]Drug Discovery and Development Center,Office of Advanced Science and Technology,Thammasat University(Rangsit Campus),Pathum Thani 12121,Thailand [2]Department of Botany and Biodiversity Research,University of Vienna,Rennweg 14,Vienna A-1030,Austria [3]Institute of Chemistry of Renewable Resources,University of Natural Resources and Life Sciences Vienna(BOKU),Tulln an der Donau A-3430,Austria [4]Department of Food Chemistry,Faculty of Pharmacy,Mahidol University,Bangkok 10400,Thailand

出　　处：《Chinese Herbal Medicines》2020年第4期452-455,共4页中草药（英文版）

基　　金：financial support provided by Thammasat University Research Fund under the TU Research Scholar,Contract No.2/29/2561。

摘　　要：Objective:To isolate and identify the major bioactive components from the leaves of Lysiphyllum strychnifolium,an indigenous herb used in traditional Thai medicine for detoxification,longevity,and some other health related issues.Methods:Comparative HPLC analyses of the crude extracts from three provenances were carried out for an overview of characteristic compound profiles.Isolation of the major compounds was undertaken with chromatographic methods.Chemical structures were elucidated by NMR spectroscopic techniques and mass spectrometry.DPPH scavenging assay was carried out to determine the free radical scavenging activity of isolated compounds.Results:Yanangdaengin(3),a dihydrochalcone glucoside galloyl ester,has been isolated together with its corresponding dihydrochalcone glucoside trilobatin(2)as major compounds from the leaves of L.strychnifolium.Additionally,gallic acid(1)was co-chromatographically identified.Free radical scavenging activity of isolated compounds were determined.Compound 3 exhibited higher free radical scavenging activities in comparison to Trolox and quercetin.Conclusion:The isolated compounds could be used as chemical markers for quality assessment.The present work could promote the quality control and herbal medicinal product development of this plant.

关 键 词：antioxidative properties Bauhinia strychnifolia Craib DIHYDROCHALCONE Lysiphyllum strychnifolium(Craib)A.Schmitz Ya-Nang-Daeng 

分 类 号：R284[医药卫生—中药学]