多指标综合加权评分法优选复方夏枯草洗剂提取工艺研究  

Optimizing extraction process of Compound Xiakucao Lotion by comprehensive evaluation of multiple mark

作　　者：陆雪琴[1] 赵亮 周洁[1] 段彦娟[1] 张春燕[3] 朱建勇[3] 翟晓翔 LU Xueqin;ZHAO Liang;ZHOU Jie;DUAN Yanjuan;ZHANG Chunyan;ZHU Jianyong;ZHAI Xiaoxiang(Department of Dermatology,Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China;Nanjing University of Chinese Medicine,Nanjing 210023,China;Central Laboratory,Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属第七人民医院皮肤科,上海200137 [2]南京中医药大学,南京210023 [3]上海中医药大学附属第七人民医院中心实验室,上海200137

出　　处：《天津中医药》2020年第12期1431-1435,共5页Tianjin Journal of Traditional Chinese Medicine

基　　金：2018年度浦东新区“国家中医药发展综合改革试验区”建设项目(PDZY-2018-0803);国家自然科学基金青年基金项目(8150140723);上海市卫生和计划生育委员会科研项目(20194Y0424);浦东新区卫生和计划生育委员会临床中医高原学科建设项目(PDZT-2018-0604)。

摘　　要：[目的]优选复方夏枯草洗剂的提取工艺。[方法]采用L9(34)正交设计,以迷迭香酸、丹酚酸B的含量及出膏率的综合评分为指标,考察料液比、提取时间、提取次数对提取效果的影响,优选复方夏枯草洗剂的最佳提取工艺。[结果]根据综合评分的结果,优选出最佳提取工艺为加8倍水,提取3次,每次0.5 h。[结论]该工艺准确可靠,可行性好。[Objective]To investigate the extraction process of Compound Xiakucao Lotion.[Methods]Orthogonal test was used to investigate effects of solid-liquid ratio,extraction time,and times on extraction process.The extraction process was optimized by comprehensive evaluation indexes based on the content of rosmarinic acid,salvianolic acid B,and the extraction yield.[Results]According to the result of comprehensive score,the optimal extraction conditions of this preparation were as follows:extracted twice with 8 times of water quantity,each for half one hour.[Conclusion]The optimized process is accurate,reliable and feasible for the industrial production of Compound Xiakucao Lotion.

关 键 词：复方夏枯草洗剂 正交实验 迷迭香酸 丹酚酸B 综合加权评分法 

分 类 号：R284.2[医药卫生—中药学]