北京社区人群生活方式与皮肤晚期糖基化终产物自发荧光相关性的研究  

The association between lifestyle and skin autofluorescence of advanced glycation end products in a community population in Beijing

作　　者：刘林[1] 张健[1] 刘薇[1] 黄有媛[1] 贾佳[2] 王淑玉[6] 张洋[3] 王贻坤[3] 东黎光[4] 王安平[5] 司莫奎 高莹[1] 张俊清[1] LIU Lin;ZHANG Jian;LIU Wei(Department of Endocrinology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院内分泌科,100034 [2]北京大学第一医院心内科,100034 [3]中国科学院合肥物质科学研究院应用技术研究所 [4]北京大学首钢医院古城社区服务中心 [5]中国人民解放军总医院内分泌科 [6]中国高血压联盟研究所

出　　处：《中国糖尿病杂志》2020年第11期833-837,共5页Chinese Journal of Diabetes

基　　金：北京市科技计划课题(D171100002817001);中国科学院科技服务网络计划(KFJ⁃STS⁃ZDTP⁃063);中国科学院国际合作局对外合作重点项目(116134KYSB20170018)。

摘　　要：目的探讨北京社区人群生活方式与AGEs皮肤自发荧光(SAF)的相关性。方法对北京某社区>40岁6055名居民横断面调查,进行SAF检测、体格检查、血糖检测及生活方式问卷调查。结果校正年龄、性别、BMI、BG后,生活方式中吸烟、饮茶、喝咖啡、日间睡眠、运动与SAF相关(β=0.152、0.025、0.046、0.041、―0.049,P<0.05或P<0.01)。亚组分析显示,<60岁人群饮茶与SAF不相关,高盐饮食与SAF呈负相关(β=―0.044,P=0.040)。>60岁人群咖啡摄入与SAF不相关,高盐饮食与SAF呈正相关(β=0.032,P=0.036)。将饮茶种类、年茶叶消耗量、饮茶时间纳入多元线性回归分析后显示,SAF与年茶叶消耗量相关(β=0.084,P<0.001)。结论吸烟、饮茶、咖啡、高盐饮食、日间睡眠、运动等生活方式与SAF相关,饮茶对SAF影响主要取决于年茶叶消耗量。Objective To investigate the association between lifestyle and skin autofluorescence(SAF)of advanced glycation end products in a community population in Beijing.Methods A cross⁃sectional survey was conducted among 6055 residents aged over 40 years in a community in Beijing.SAF,physical examination,blood glucose(BG)and lifestyle questionnaire were performed in all the participants.Results After adjusting for age,gender,body mass index(BMI)and BG,the following lifestyles:smoking,drinking tea or coffee,daytime sleeping,physical exercise were independently correlated with SAF(β=0.152,0.025,0.046,0.041,―0.049,P<0.05 or P<0.01).Subgroup analysis showed that in population<60 years old,tea consumption was not associated with SAF,but high salt diet was negatively associated with SAF(β=―0.044,P=0.040).In population>60 years old,coffee consumption was not associated with SAF,but high salt diet was associated with SAF(β=0.032,P=0.036).Multivariate linear regression showed that after adjusting tea kinds,and tea drinking time,total tea consumption per year was independently correlated with SAF(β=0.084,P<0.01).Conclusion Smoking,drinking tea or coffee,salty diet,daytime sleeping and physical activities are independently related to SAF.The influence of drinking tea on SAF was mainly determined by total tea consumption.

关 键 词：晚期糖基化终产物 皮肤自发荧光 生活方式 茶 

分 类 号：R587.2[医药卫生—内分泌]