白色脂肪褐变影响因素的研究进展  

Research progress on factors influencing browning of white fat

作　　者：樊德慧 金娟[3] 韩宇博[3] 田苗 刘莉[3] FAN Dehui;JIN Juan;HAN Yubo(The First Clinical Medical College of Heilongjiang University of Chinese Medicine,Haerbin 150040,China)

机构地区：[1]黑龙江中医药大学第一临床医学院,哈尔滨150040 [2]黑龙江中医药大学实验实训中心,哈尔滨150040 [3]黑龙江中医药大学附属第一医院心血管科

出　　处：《中国糖尿病杂志》2020年第11期874-877,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81873284);黑龙江省博士后资助经费项目(LBH⁃Z18253);黑龙江中医药大学双一流及优势特色学科建设项目(HLJSYL1001);黑龙江中医药大学校科研基金科技创新团队项目(2019TD01);黑龙江中医药大学校科研基金博士创新项目(2019BS02);黑龙江中医药大学研究生创新基金(2020yjscx005)。

摘　　要：MS是一组以肥胖、BG、BP、血脂异常为临床特征的代谢异常综合征,肥胖是发病的主要原因。人体脂肪组织分为白色脂肪组织(WAT)和棕色脂肪组织(BAT),WAT以TG形式储存能量,BAT消耗能量。长期能量摄入与消耗的不平衡导致脂肪堆积是引起肥胖的主要原因。WAT褐变的脂肪组织和BAT有相似功效,通过解偶联蛋白1依赖形式,利用脂肪酸消耗储存的能量以达到减肥目的。通过诱导体内WAT褐变可能是拮抗MS脂肪堆积的有效途径。本文对体内因子WAT褐变的诱导作用进行综述,为治疗肥胖和MS提供新思路。metabolic syndrome(MS)is a group of metabolic disorders characterized by obesity,abnormal blood glucose,abnormal blood pressure and abnormal blood lipid.Obesity is one of the key factors for its onset.The adipose tissue of human body is divided into white adipose tissue(WAT)and brown adipose tissue(BAT).WAT stores energy in the form of triglycerides,while BAT is responsible for consuming energy.Fat accumulation is the main cause of obesity due to long⁃term imbalance between energy intake and consumption.Recently,it has been discovered that browning WAT has similar efficacy to BAT.Uncoupling protein 1(UCP1)utilizes fatty acids to consume stored energy through a form⁃dependent manner,thereby achieving the goal of weight loss.Therefore,inducing browning of WAT in vivo may be an effective way to antagonize fat accumulation caused by MS.This article aims to provide new ideas for the treatment of obesity and MS by exploring the effect of in vivo influence factors on browning of WAT.

关 键 词：白色脂肪组织褐变 棕色脂肪组织 解偶联蛋白1 肥胖 代谢综合征 

分 类 号：R589.2[医药卫生—内分泌]