Design,Synthesis,Biological Evaluation and SARs of Anthranilic Diamide Derivatives Containing Pyrrole Moieties  

作　　者：ZHAO Yangyang LI Huangong SUN Pengwei GAO Li ZHOU Sha XIONG Lixia YANG Na LI Yuxin LI Zhengming 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry,Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,P.R.China

出　　处：《Chemical Research in Chinese Universities》2020年第6期1168-1173,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Key Research and Development Program of China(Nos.2018YFD0200100,2017YFD0200505);the National Natural Science Foundation of China(Nos.31972287,21602118).

摘　　要：In order to find a new variety of ryanodine receptor(RyR)regulator with greater biological activity,a se-ries of anthranilic diamide derivatives possessing pyrrole structure was designed and synthesized in this study.The pyrrole derivatives were evaluated for their insecticidal activity against Mythimna separata and Plutella xylostella.As indicated by the preliminary biological activities,compounds 12h-12j and 121-12n exhibited a remarkable in-secticidal activity against M.separata at 0.25 mg/L.Compared to control chlorantraniliprole.compound 12i exhibited more excellent insecticidal activity at 0.1 mg/L.Meanwhile,compounds 12c,12h,12i.12j.121,and 12m were selected to test the insecticidal activity against P xylostella,which led to the desirable insecticidal activity at 1x103 mg/L.Notably,compound 121 demonstrated 47%insecticidal activity at 5×10^(-6) mg/L over the control.In addition,the biological mechanism of action of compound 12i was investigated by means of insect clectrophysiology experiment.

关 键 词：Ryanodine receptors(RyRs)activator PYRROLE Anthranilic diamide Insecticidal activity Mechanism of action 

分 类 号：O62[理学—有机化学]