外泌体在乳腺癌诊治中的研究进展  

The Progress of Exosomes Application in Diagnosis and Treatmeat of breast cancer

作　　者：梅兆玲 周文辉[2] 冯景 MEI Zhaoling;ZHOU Wenhui;FENG Jing(Medical school,Anhui University of Science and Technology,Huainan 232001,China;Department of Clinical Laboratory,Anhui University of Science and Technology Affiliated Fengxian Hospital,Shanghai 201499,China)

机构地区：[1]安徽理工大学医学院,安徽淮南232001 [2]安徽理工大学附属奉贤医院检验科,上海201499

出　　处：《检验医学》2020年第12期1203-1206,共4页Laboratory Medicine

基　　金：国家自然科学基金面上项目(81672624);国家自然科学基金面上项目(81772817);上海市医学领军人才培养计划(2019LJ25);上海健康医学院协同创新重点专项(SPCI-17-15-001)。

摘　　要：外泌体是由大多数细胞产生的脂质双层小囊泡,囊泡内包含丰富的核酸、蛋白质和脂质等物质。外泌体对于乳腺癌等肿瘤的发生、发展具有显著的调控作用。乳腺癌细胞来源的外泌体具有显著的细胞特异性,在乳腺癌的早期诊断中具有重要的应用价值。由于外泌体具有良好的生物相容性、体内循环能力及物质运载能力,因此被广泛用于乳腺癌治疗药物的研究中。文章对外泌体在乳腺癌诊疗中的研究进展进行概述,总结了当前乳腺癌外泌体研究面临的主要问题。Exosomes are small lipid bilayer vesicles,which contents nucleic acids,proteins,lipids and lots of other things.Exosomes have great potential to regulator the occurrence and development of breast cancer.Exosomes derived from breast cancer cells have great potential in the application of early diagnosis and prognosis of breast cancer.Otherwise,the great biocompatibility,natural circulation ability,and strong loading capacity makes exosomes widely used in the developing of drugs for breast cancer treatment.This article gives a brief overview of its application in diagnosis and treatment of breast cancer,the main problems were summarized.

关 键 词：外泌体 微小RNA 乳腺癌 靶向治疗 

分 类 号：R446.1[医药卫生—诊断学]