153例多发性骨髓瘤的细胞遗传学分析  被引量:3

Cytogenetic analysis of 153 newly-diagnosed cases of multiple myeloma

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作  者:徐凯红[1] 牧启田[1] 欧阳桂芳[1] 严笑[1] XU Kaihong;MU Qitian;OUYANG Guifang;YAN Xiao(Department of Hematology,Ningbo First Hospital,Ningbo 315000,Zhejiang,China)

机构地区:[1]宁波市第一医院血液科,浙江宁波315000

出  处:《检验医学》2020年第12期1243-1247,共5页Laboratory Medicine

基  金:宁波市自然科学基金(2017A610210、2017A610177)。

摘  要:目的评价细胞遗传学分析在多发性骨髓瘤(MM)中的应用价值。方法采用核型分析和间期荧光原位杂交(iFISH)对153例MM的细胞遗传学结果进行回顾性分析。结果MM患者染色体异常主要集中在13、9、14、1、8号染色体上;核型分析联合iFISH染色体异常检出率可达79.1%,多数为复杂的染色体异常,其中9例染色体核型异常,但iFISH阴性;在这9例中,有7例患者的无疾病进展时间(PFS)<3年,其中2例患者死于感染和心力衰竭。结论常规染色体核型分析能提供完整的细胞遗传学资料,虽然检出率偏低,但是在科学研究和临床应用中仍不可或缺。Objective To evaluate the role of cytogenetic analysis in multiple myeloma(MM).Methods The cytogenetic analysis in 153 newly-diagnosed cases of MM was performed retrospectively.Results The recurrent chromosomal abnormality were most concentrated on the chromosome 13,9,14,1 and 8.The combination of conventional cytogenetics and iFISH displayed genetic abnormalities up to 79.1%and showed the majority of cases had complex chromosome karyotypes.There were 9 cases of abnormal karyotypes by conventional cytogenetics,but with negative-iFISH results.The 7 of 9 cases were with progression-free survival(PFS)less than 3 years,including 2 cases of death from infection and heart failure.Conclusions Even with low efficiency,conventional cytogenetics is still an essential application for offering full cytogenetic profile,and it is still indispensable for current scientific research and clinical practice.

关 键 词:多发性骨髓瘤 细胞遗传学 染色体核型 

分 类 号:R446.1[医药卫生—诊断学]

 

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