免疫球蛋白治疗儿童重症病毒性脑炎的临床效果  

Clinical effect of immunoglobulin in the treatment of severe viral encephalitis in children

作　　者：李东景[1] 马楠[1] LI Dongjing;MA Nan(Xi'an Children's Hospital,Xi'an 710003,China)

机构地区：[1]西安市儿童医院,陕西西安710003

出　　处：《临床医学研究与实践》2020年第36期166-168,共3页Clinical Research and Practice

摘　　要：目的探讨免疫球蛋白治疗儿童重症病毒性脑炎的临床效果。方法回顾性分析68例重症病毒性脑炎患儿的临床资料,按照治疗方式将患儿分为对照组与观察组,各34例。对照组给予传统治疗,观察组在对照组基础上给予人免疫球蛋白治疗。比较两组的临床效果。结果治疗后,两组的CD3^+、CD4^+均升高,CD8^+、NSE、S100β、NGF水平均降低,且观察组优于对照组(P<0.05)。观察组的昏迷苏醒时间、惊厥停止时间、体温正常时间、头痛缓解时间、呕吐消失时间均短于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。结论免疫球蛋白治疗重症病毒性脑炎患儿的效果显著,能有效调节T淋巴细胞亚群,保护神经功能细胞,改善临床症状。Objective To explore the clinical effect of immunoglobulin in the treatment of severe viral encephalitis in children.Methods The clinical data of 68 children with severe viral encephalitis were retrospectively analyzed.According to the treatment methods,the children were divided into control group and observation group,with 34 cases in each group.The control group was given traditional treatment,and the observation group was given human immunoglobulin treatment on the basis of the control group.The clinical effects of the two groups were compared.Results After treatment,the CD3^+and CD4^+in the two groups increased,while CD8^+and the levels of NSE,S100β,NGF decreased,and those in the observation group were better than the control group(P<0.05).The coma recovery time,convulsion stopping time,normal temperature time,headache relief time and vomiting disappearance time of the observation group were shorter than those of the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Conclusion Immunoglobulin in the treatment of severe viral encephalitis in children has significant effect,it can effectively regulate the T lymphocyte subsets,protect nerve function cells,and improve clinical symptoms.

关 键 词：免疫球蛋白 病毒性脑炎 神经功能细胞 

分 类 号：R725.1[医药卫生—儿科]