浙贝母花化学成分研究  

Chemical constituents of flowers of Fritillariae Thunbergii Miq.

作　　者：吴国真 崔明超[2,3] 姚雪[1] 潘少斌[1] 赵宏伟 刘伟[4] 李佳[1] WU Guo-zhen;CUI Ming-chao;YAO Xue;PAN Shao-bin;ZHAO Hong-wei;LIU Wei;LI Jia(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Traditional Chinese Medicine,Zhejiang Pharmaceutical College,Ningbo 315100,China;Colloge of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210023,China;Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences),Jinan 250014,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]浙江医药高等专科学校中药学院,浙江宁波315100 [3]南京中医药大学药学院,江苏南京210023 [4]齐鲁工业大学(山东省科学院)山东省分析测试中心,山东济南250014

出　　处：《山东科学》2020年第6期22-26,共5页Shandong Science

基　　金：浙江医药高等专科学校校级科研课题(ZPCSR2017011);2018年度山东中医药大学科学基金(2018zk33)。

摘　　要：对浙贝母花95%乙醇提取物的乙酸乙酯部位进行化学成分研究。运用正相硅胶柱色谱、反相C18中压柱色谱及半制备高效液相色谱进行分离纯化,通过核磁共振波谱及质谱鉴定得到化合物的结构。从浙贝母花乙酸乙酯部位共分离得到8种化合物,分别为正二十九烷(1)、亚油酸(2)、棕榈酸(3)、反式阿魏酸(4)、反式对羟基桂皮酸(5)、咖啡酸(6)、七叶内酯(7)、顺式对羟基桂皮酸(8),均为首次从浙贝母花中分离得到。Chemical constituents of the ethyl acetate part from 95%ethanol extract of flowers of Fritillariae Thunbergii Miq.were studied herein.Positive silica gel column chromatography,reverse C18 medium pressure column chromatography,and semi-preparative high performance liquid chromatography were used for the separation and purification.The structures of the obtained compounds were identified using NMR and MS.From the ethyl acetate extract of the flowers of Fritillariae Thunbergii Miq.,eight compounds were isolated and identified,which included n-nonacosane(1),linoleic acid(2),palmitic acid(3),trans-ferulic acid(4),trans-p-hydroxy cinnamic acid(5),caffeic acid(6),esculetin(7),and Z-p-hydroxyl cinnamic acid(8).To the best of our knowledge,compound 1~8 are all isolated from this plant for the first time.

关 键 词：贝母花 提取分离 化学成分 

分 类 号：R284.2[医药卫生—中药学]