SLC7A11与Ki-67在喉鳞状细胞癌中的表达及临床意义  

Expression of SLC7A11 and Ki-67 in Laryngeal Carcinoma and the Clinical Significance

作　　者：李清华 马志红[1] 李立[1] 唐艳丽[1] 陈宝刚[1] 唐桂华[1] LI Qinghua;MA Zhihong;LI Li(Chengde Central Hospital,Hebei Chengde 067000,China)

机构地区：[1]河北省承德市中心医院耳鼻喉科,河北承德067000

出　　处：《河北医学》2020年第12期1978-1982,共5页Hebei Medicine

基　　金：河北省承德市科学技术研究与发展计划项目,(编号:201801A004)。

摘　　要：目的:观察喉癌组织SLC7A11、Ki-67的表达情况,探讨其在喉癌预后、复发等的作用。方法:利用免疫组化SP方法检测117例喉癌组织(喉癌组)和65例声带息肉组织(对照组)SLC7A11、Ki-67的表达,采用卡方检验分析喉癌组织中SLC7A11、Ki-67的表达与患者预后、复发的关系。结果:喉癌组中SLC7A11、Ki-67阳性率均高于对照组(χ^2分别为9.630、8.006,P<0.05)。喉癌组织中的SLC7A11阳性表达、Ki-67阳性表达与肿瘤临床分期及术后复发相关(P<0.05),与患者生存率无统计学相关性。结论:喉癌组织中SLC7A11、Ki-67的高表达,两者与患者肿瘤临床分期、术后复发有关,对患者预后有重要意义。Objective:To observe the expression of SLC7A11 and Ki-67 in laryngeal carcinoma,and to explore its role in the occurrence and progression of laryngeal carcinoma.Methods:The relative expression of SLC7A11 and Ki-67 in 117 cases of laryngeal carcinomas tissues(laryngeal carcinoma group)and 65 cases of vocal polyps(control group)was detected by immunohistochemical SP method.The relationship between the expression and the clinicopathological features of laryngeal carcinoma was analyzed.Chi-square test was used to analyze the relationship between SLC7A11 and Ki-67 expression and prognosis and recurrence of patients with laryngeal carcinoma.Results:The positive expression levels of and SLC7A11 and Ki-67 were higher in the laryngeal carcinoma group than in the control group(χ^2=9.630、8.006,both P<0.05).High expression of SLC7A11 and Ki-67 was associated with high clinical stage of laryngeal cancer(P<0.05).And it was not related to the survival of patients with laryngeal cancer.Conclusion:The high expression of SLC7A11 and Ki-67 in the laryngeal carcinoma are related to the disease progression and postoperative recurrence,and it is important for the prognosis of patients.

关 键 词：喉肿瘤 SLC7A11 KI-67 预后 复发 

分 类 号：R739.65[医药卫生—肿瘤]