红油膏联合光子治疗仪对肛瘘术后患者创面愈合及抗炎作用机制探讨  

The Mechanism of Wound Healing and Anti-Inflammatory Effect of Red Ointment Combined with Photon Therapy Instrument in Patients with Anal Fistula After Operation

作　　者：顾菁华 杜培欣[1] 梅祖兵[1] GU Jinghua;DU Peixin;MEI Zubing(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200221,China)

机构地区：[1]上海中医药大学附属曙光医院肛肠科,上海200221

出　　处：《河北医学》2020年第12期1982-1986,共5页Hebei Medicine

基　　金：国家自然科学基金面上项目,(编号:81774112)。

摘　　要：目的:探讨分析红油膏联合光子治疗仪对肛瘘术后患者创面愈合及抗炎作用机制。方法:选择2018年3月至2019年4月在我院行切开手术治疗的肛瘘患者93例,随机分为观察组47例、对照组46例,对照组患者术后第1d其常规换药后创面涂抹红油膏,观察组在对照组基础上使用光子治疗仪对创面进行局部照射。比较两组患者术后14d临床疗效、术后VAS评分、创面面积情况、创面愈合时间以及血清白介素-4(IL-4)、白介素-17(IL-17)及肿瘤坏死因子-α(TNF-α)水平变化。结果:观察组患者临床治疗总有效率显著高于对照组(P<0.05)。术后1d、术后14d两组患者VAS评分无显著差异(P>0.05),而术后3d、术后7d观察组患者VAS评分显著低于对照组(P<0.05)。术后1d、术后3d两组患者创面面积无显著差异(P>0.05),术后7d、术后14d观察组患者创面面积显著低于对照组(P<0.05)。观察组患者创面愈合时间显著短于对照组(P<0.05)。术后7d两组患者血清IL-4、IL-7以及TNF-α水平均较术后1d显著降低(P<0.05),且术后7d观察组患者血清IL-4、IL-7以及TNF-α水平显著低于对照组(P<0.05)。结论:红油膏联合光子治疗仪可有效缓解肛瘘患者术后疼痛,有助于促进患者术后创面的愈合,其作用可能与抑制机体炎症反应有关,值得临床推广。Objective:To explore the mechanism of red ointment combined with photon therapy on wound healing and anti-inflammatory in patients with anal fistula.Methods:From March 2018 to April 2019,93 patients with anal fistula who were operated on in our hospital were randomly divided into observation group(47 cases)and control group(46 cases).On the first day after operation,the patients in the control group were treated with red ointment after routine dressing change,and the observation group was treated with photon therapy instrument on the basis of the control group.The clinical effect,VAS score,edema,wound healing time,serum levels of IL-4,IL-17 and TNF-α were compared between the two groups.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in VAS score between the two groups on the first day after operation(P>0.05),but the VAS score of the observation group was significantly lower than that of the control group on the third day and the seventh day after operation(P<0.05).There was no significant difference in the area of wound between the two groups(P>0.05),and the area of wound in the observation group was significantly lower than that in the control group(P<0.05).The wound healing time of the observation group was significantly shorter than that of the control group(P<0.05).The levels of IL-4,IL-7 and TNF-α in the two groups were significantly lower than those in the first day after operation(P<0.05),and the levels of IL-4,IL-7 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:The combination of red oil ointment and photon therapy instrument can effectively relieve the postoperative pain of patients with anal fistula and promote the wound healing.Its effect may be related to the inhibition of inflammatory response of the body,which is worthy of clinical promotion.

关 键 词：红油膏 光子治疗仪 肛瘘术后 创面愈合 抗炎作用 

分 类 号：R657.16[医药卫生—外科学]