乳酸脱氢酶白介素-8及血栓素B2在无菌性脓疱病中的含量变化及意义  

Change and Significance of Lactate Dehydrogenase,Interleukin-8 and Thromboxane B2 Levels in Aseptic Pustulosis

作　　者：张慧娟[1] ZHANG Huijuan(The Seventh People's Hospital of Shenyang,Liaoning Shenyang 110003,China)

机构地区：[1]辽宁省沈阳市第七人民医院皮肤科,辽宁沈阳110003

出　　处：《河北医学》2020年第12期2065-2069,共5页Hebei Medicine

基　　金：辽宁省科学技术计划项目,(编号:2015010551-301)。

摘　　要：目的:分析乳酸脱氢酶(lactate dehydrogenase,LDH)、白介素-8(Interleukin-8,IL-8)及血栓素B2(Thromboxane B2,TXB2)在无菌性脓疱病中的含量变化及意义。方法:收集2017年8月至2019年9月本院皮肤科收治的112例无菌性脓疱病患者的临床资料,另选取同期在本院进行体检健康人98例作为正常组。对比不同人群LDH、IL-8、TXB2含量差异,并分析LDH、IL-8、TXB2与无菌性脓疱病相关性。结果:无菌性脓疱病组患者血液中LDH、IL-8、TXB2含量明显高于正常组(P<0.05);治疗后LDH、IL-8、TXB2均为明显下降趋势(P<0.05);112患者治疗后,预后良好者有87例,预后不良为25例,LDH、IL-8、TXB2含量在预后良好中明显低于预后不良者(P<0.05);通过Logistic回归分析,发现不同分型、LDH、IL-8、TXB2为影响无菌性脓疱病患者预后不良的独立危险因素(P<0.05)。结论:LDH、IL-8、TXB2在无菌性脓疱病患者中含量较高,指标含量的变化可为临床诊断、病情监测、预后评估提供参考。Objective:To analyze the change of content and significance of lactate dehydrogenase(LDH),interleukin-8(IL-8)and thromboxane B2(TXB2)in aseptic pustulosis.Method:The clinical data of 112 patients with aseptic pustulosis admitted to our hospital's dermatology department from August 2017 to September 2019 were collected,and 98 healthy controls were selected as the normal group.The differences in the content levels of LDH,IL-8 and TXB2 in different people were compared,and the correlation between LDH,IL-8 and TXB2 and aseptic pustulosis was analyzed.Results:The content levels of LDH,IL-8 and TXB2 in the blood of the patients in aseptic pustulosis group were significantly higher than those in the normal group(P<0.05).After treatment,the levels of LDH,IL-8,and TXB2 all decreased significantly(P<0.05).After treatment in 112 patients,there were 87 cases with good prognosis and 25 cases with grim prognosis.The content levels of LDH,IL-8 and TXB2 in patients with the good prognosis were significantly lower than those in patients with grim prognosis(P<0.05).Logistic regression analysis showed that different types,LDH,IL-8,and TXB2 were independent risk factors that affected the grim prognosis of patients with aseptic pustulosis(P<0.05).Conclusion:LDH,IL-8,and TXB2 content levels all show high expression in patients with aseptic pustulosis,and the change of index can provide a reference for clinical diagnosis,monitoring of disease,and evaluation of prognosis.

关 键 词：乳酸脱氢酶 白介素-8 血栓素B2 无菌性脓疱病 

分 类 号：R753.1[医药卫生—皮肤病学与性病学]