代谢性疾病的肠道菌群相关研究进展  

Intestinal microflora in metabolic diseases

作　　者：李玉丽 肖嫩群[1] 谭周进[1] Yu-Li Li;Nen-Qun Xiao;Zhou-Jin Tan(School of Medicine,College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,Hunan Province,China)

机构地区：[1]湖南中医药大学药学院,湖南中医药大学医学院,湖南省长沙市410208

出　　处：《世界华人消化杂志》2020年第23期1192-1199,共8页World Chinese Journal of Digestology

基　　金：湖南省自然科学基金,No.2020JJ4468.

摘　　要：代谢性疾病是指葡萄糖、蛋白质及脂质在体内代谢异常引起的一类疾病.越来越多的证据支持肠道菌群失调与代谢性疾病具有重要的相关性.具体而言,肠道菌群失调可能破坏肠道屏障功能,诱发内毒素血症、胆汁酸代谢紊乱和全身慢性低度炎症,促进代谢性疾病进展及并发症发生.随着代谢性疾病病情进展,肠道内环境改变以及药物、饮食等影响又反过来加重肠道菌群失调,最终引起预后不良.这凸显了通过调节肠道菌群结构来开发防治代谢性疾病治疗策略的可能性.益生菌、益生元和合生元疗法、粪菌移植、中医药等可通过维持肠道菌群平衡、对抗有害菌群产物,从而治疗代谢性疾病.本文从代谢性疾病肠道菌群变化、肠道菌群影响代谢性疾病的可能机制、肠道菌群在代谢性疾病治疗中的应用等方面进行综述,以期为以肠道菌群为靶点的代谢性疾病的诊断防治研究提供借鉴.Metabolic diseases are a class of diseases caused by abnormal metabolism of glucose,protein,and lipids in the body.Accumulating evidence supports the important relevance of intestinal dysbacteriosis to metabolic diseases.Specifically,intestinal dysbacteriosis may disrupt intestinal barrier function,thereby inducing endotoxemia,bile acid metabolism disorders,and systemic chronic low-grade inflammation,which promote metabolic disease progression and complications.With the progression of the disease,the change in intestinal environment and the influence of drugs and diet in turn aggravate the imbalance of intestinal flora,which eventually leads to poor prognosis.This highlights the potential for developing therapies to prevent and treat metabolic diseases by changing the intestinal bacterial structure.Probiotics,prebiotics,synbiotic therapy,fecal bacteria transplantation,and traditional Chinese medicine can be used to treat metabolic diseases by maintaining the balance of intestinal bacteria and counteracting harmful bacterial products.This article reviews the changes of intestinal bacteria in metabolic diseases,the possible mechanism of intestinal bacteria affecting metabolic diseases,and the application of intestinal bacteria in the treatment of metabolic diseases,with an aim to provide a reference for the diagnosis and prevention of metabolic diseases by targeting intestinal flora.

关 键 词：代谢性疾病 肠道菌群 肥胖 糖尿病 非酒精性脂肪肝 

分 类 号：R589[医药卫生—内分泌]