抗肺结核治疗患者血清炎症因子动态变化  

Dynamic change of serum inflammatory factors of patients with tuberculosis

作　　者：陈永宏[1] 肖江峰[1] 陈瑞华[1] 田冰[1] 向江琳[1] CHEN Yong-hong;XIAO Jiang-feng;CHEN Rui-hua;TIAN Bing;XIANG Jiang-lin(Chongqing Three Gorges Central Hospita l,Chongqing 400100,China)

机构地区：[1]重庆三峡中心医院感染科,重庆400100

出　　处：《中华医院感染学杂志》2020年第21期3293-3296,共4页Chinese Journal of Nosocomiology

基　　金：重庆市自然科学基金资助项目(2007BB5032)。

摘　　要：目的分析抗肺结核治疗患者血清促炎及抗炎因子动态变化。方法回顾性收集2016年1月-2017年12月重庆三峡中心医院收治的200例肺结核患者的临床资料,所有患者进行抗结核治疗3个月时进行痰液涂片检测,分为痰液阳性组和痰液转阴组;比较两组患者治疗前、治疗3个月、治疗6个月血清中促炎因子肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、IL-6、干扰素-γ(IFN-γ)及抗炎因子IL-10、IL-4、转化生长因子-β(TGF-β)的含量,以及肺部病灶的吸收情况。结果与治疗前相比,痰液转阴组患者治疗后3个月及6个月血清中TNF-α、IL-1、IL-6及IFN-γ含量降低(P<0.05);IL-10、IL-4及TGF-β升高(P<0.05);痰液阳性组血清TNF-α、IL-1及IFN-γ的含量仅在治疗后6个月降低(P<0.05);IL-6的含量在治疗后3个月及6个月血清中的含量降低(P<0.05);痰液阳性组血清IL-10、IL-4及TGF-β的含量仅在治疗后6个月升高(P<0.05);治疗后3个月及6个月,痰液转阴组血清中TNF-α、IL-1、IL-6及IFN-γ的含量均降低(P<0.05);IL-10、IL-4及TGF-β的含量均升高(P<0.05);与痰液阳性组相比,痰液转阴组患者治疗后6个月、12个月的肺部病灶吸收率增加(P<0.05)。结论治疗效果良好的肺结核患者血清中促炎细胞因子的含量降低,抗炎细胞因子的含量升高,检测血清中促炎细胞因子及抗炎细胞因子的含量,能够对肺结核的治疗提供参考。OBJECTIVE To analyze the dynamic changes of serum pro-inflammatory and anti-inflammatory factors of the patients with pulmonary tuberculosis.METHODS The clinical data were retrospectively collected from 200 pulmonary tuberculosis patients who were treated in Chongqing Three Gorges Central Hospital from Jan 2016 to Dec 2017,the sputum smear test was carried out for all of the patients after the anti-tuberculosis treatment for 3 months,the patients were divided into the sputum positive group and the sputum negative group.The levels of serum proinflammatory factors tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),IL-6,interferon-γ(IFN-γ)and anti-inflammatory factors IL-10,IL-4 and transforming growth factor-β(TGF-β)were compared between the two groups of patients before the treatment and after the treatment for 3 and 6 months,and the absorption of lung lesions was observed.RESULTS The levels of serum TNF-α,IL-1,IL-6 and IFN-γof the sputum negative group were significantly lower after the treatment for 3 and 6 months than before the treatment(P<0.05),the levels of IL-10,IL-4 and TGF-βwere significantly elevated(P<0.05).The levels of serum TNF-α,IL-1 and IFN-γof the sputum positive group were significantly reduced after the treatment for 6 months(P<0.05);the IL-6 level was significantly reduced after the treatment for 3 and 6 months(P<0.05);the levels of serum IL-10,IL-4 and TGF-βof the sputum positive group was significantly elevated after the treatment for 6 months(P<0.05).The levels of serum TNF-α,IL-1,IL-6 and IFN-γof the sputum negative group were significantly reduced after the treatment for 3 and 6 months(P<0.05);the levels of IL-10,IL-4 and TGF-βwere significantly elevated(P<0.05).The absorption rate of lung lesions of the sputum negative group was significantly higher than that of the sputum positive group after the treatment for 6 and 12 months(P<0.05).CONCLUSION The levels of serum proinflammatory factors of the tuberculosis patients who have favorable curative effect are reduced,while the

关 键 词：肺结核 促炎细胞因子 抗炎细胞因子 治疗效果 

分 类 号：R521[医药卫生—内科学]