女性尖锐湿疣HPV感染亚型分布及 Th1/Th2细胞免疫失衡研究  

Subtypes of HPV of women with condyloma acuminatum and Th1/Th2 cell immune imbalance

作　　者：宋元梓 张春华[1] 康凌[1] 宋晓玲[1] 李小华[1] SONG Yuan-zi;ZHANG Chun-hua;KANG Ling;SONG Xiao-ling;LI Xiao-hua(Nanyang Second Peoples Hospital Nanyang,Henan 473000,China)

机构地区：[1]南阳市第二人民医院妇一科,河南南阳473000

出　　处：《中华医院感染学杂志》2020年第21期3341-3345,共5页Chinese Journal of Nosocomiology

基　　金：河南省自然科学基金资助项目(2019385)。

摘　　要：目的探讨女性人乳头瘤病毒(HPV)感染尖锐湿疣(CA)亚型分布与辅助性T细胞1/辅助性T细胞2(Th1/Th2)细胞免疫失衡相关性研究。方法选取南阳市第二人民医院皮肤科2016年1月-2019年1月收治的女性CA患者86例作为CA组,另选取同期医院妇科收治的HPV阳性非CA女性40例作为非CA组,对两组患者一般性资料如年龄、病程等进行收集统计。结果 CA患者以低危型HPV感染为主,占62.79%,其中HPV6、HPV11检出率较高,高危感染占27.91%,混合感染占9.30%;CA组Th1%、Th1/Th2及IFN-γ水平低于非CA组患者,Th2%、IL-4、IL-10水平高于非CA组患者,差异具有统计学意义(P<0.05);低危型、高危型、混合型HPV感染CA患者三者整体Th1%、Th2%、Th1/Th2、IFN-γ、IL-4、IL-10比较无统计学差异;CA患者,复发组Th1%、Th1/Th2及IFN-γ水平低于非复发组,Th2%、IL-4水平高于非复发组,差异具有统计学意义(P<0.05),但两组IL-10水平比较无统计学差异。结论 HPV感染尖锐湿疣女性伴随着明显的Th1/Th2免疫失衡,与病毒亚型无关,与疾病复发有关,有作为免疫靶向治疗的潜力,值得进一步研究。OBJECTIVE To explore the correlation between the subtypes of human papilloma virus(HPV)in women with condyloma acuminatum(CA)and the immune imbalance of helper T cell 1/helper T cell 2(Th1/Th2).METHODS Totally 86 women with CA who were treated in department of dermatology of Nanyang Second People’s Hospital from Jan 2016 to Jan 2019 were chosen as the CA group,meanwhile,40 HPV-positive women without CA who were treated in gynecology department were set as the non-CA group.The baseline data such as age and course of disease were collected from the two groups of patients and were analyzed.RESULTS The CA patients with low-risk HPV infection were dominant,accounting for 62.79%;the isolation rates of HPV6 and HPV11 were high,the patients with high risk infection accounted for 27.91%,and the patients with mixed infection accounted for 9.30%.The Th1%,Th1/Th2 and IFN-γlevel of the CA group were significantly lower than those of the non-CA group;the Th2%,IL-4 level and IL-10 level of the CA group were significantly higher than those of the non-CA group(P<0.05).Among the patients with CA,the Th1%,Th1/Th2 and IFN-γlevel of the recurrence group were significantly lower than those of the non-recurrence group;the Th2%and IL-4 level of the recurrence group were significantly higher than those of the non-recurrence group(P<0.05);however,there was no significant difference in the IL-10 level between the two groups.CONCLUSION The immune imbalance of Th1/Th2 of the CA women with HPV infection is not associated with the subtype of virus but is associated with the recurrence of disease,they have the potential as immune-targeted therapy and deserve further research.

关 键 词：人乳头瘤病毒 尖锐湿疣 辅助型T细胞1 辅助型T细胞2 细胞因子 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]