New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242  

作　　者：GUO Hui-Xian HUANG Cui-Ying YAN Zhang-Yuan CHEN Tao HONG Kui LONG Yu-Hua 

机构地区：[1]School of Chemistry,Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine,Souh China Normal Universiy,Guangzhou 510006,China [2]Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(Wuhan University),Ministry of Education,and Wuhan University School of Pharmaceutical Sciences,Wuhan,430071,China

出　　处：《Chinese Journal of Natural Medicines》2020年第11期855-859,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 41876153);Guangdong Special Fund for Marine Economic Development (No. GDME-2018C004);the Natural Science Foundation of Guangdong Province (No.2017A030313088)。

摘　　要：Four new compounds, asperisocoumarin G(1), asperisocoumarin H(2),(±)-asperisocoumarin I [(±)-3], along with the known pergillin(4) and penicisochroman L(5) were isolated from a mangrove endophytic fungus Aspergillus sp. 085242 by further chemical investigation. The structures of the new compounds, including their absolute configurations, were established by analysis of HR-ESI-MS and NMR spectroscopic data, and ECD calculation. Asperisocoumarins G-I(1-3) were new isocoumarins belonging to the class of furo[3, 2-h]isocoumarins which are rarely found in natural sources. All of the isolated compounds were evaluated for theirα-glucosidase inhibitory effects, and compounds 1 and 4 showed moderate α-glucosidase inhibitory activity, respectively. In an antimicrobial test, the racemate of 3 showed antibacterial activity against Salmonella.

关 键 词：ASPERGILLUS Furo[3 2-h]isocoumarins α-Glucosidase inhibitory activity Antimicrobial activity 

分 类 号：R284.1[医药卫生—中药学]