Isochlorogenic acid(ICGA): natural medicine with potentials in pharmaceutical developments  

作　　者：WANG Hao-Nan SHEN Zheng LIU Qing HOU Xiao-Ying CAO Yan LIU Da-Hui JIANG Hong DU Hong-Zhi 

机构地区：[1]Faculty of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China [2]State Key Laboratory of Natural Medicine,China Pharmaceutical University,Nanjing 210009,China [3]Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province,Hubei University of Chinese Medicine,Wuhan 430065,China [4]Hubei Institute for Drug Control,Wuhan 430064,China

出　　处：《Chinese Journal of Natural Medicines》2020年第11期860-871,共12页中国天然药物（英文版）

基　　金：supported by Hubei University of Chinese Medicine (No. 2019ZZX028)。

摘　　要：Natural products have attracted a great deal of attention as significant resources in traditional Chinese medicine(TCM)and in chemical medicine, as well as in cosmetic ingredients, nutraceuticals and food products. Isochlorogenic acid(ICGA), which has medicinal value, has been discovered in various plants. As a widespread natural medicine, ICGA should be the subject of further research and development. However, there have been no systematic analyses of ICGA. According to our investigation, ICGA was initially isolated from green coffee extracts by Barnes et al. in 1950. To date, it has been discovered in a variety of tea, vegetables, medicinal diet and TCM materials. ICGA is used as a chemical marker for the quality control of these TCM materials. The metabolic process of ICGA has been studied in detail, conforming to be linear dynamics. Thus, the clear pharmacokinetics of ICGA offers a solid foundation for its research and development. ICGA has multiple biological and pharmacological effects, and studies have mainly focused on its antioxidant, anti-inflammatory, antimicrobial, hypoglycemic, neuroprotective, and cardiovascular protective effects, and hepatoprotective properties. The mechanisms underlying these effects are summarized in this review to provide scientific support and inspiration for the future research and development of ICGA and ICGA-rich natural products.

关 键 词：Isochlorogenic acid Natural products Traditional Chinese medicine(TCM) Biological and pharmacological effects Medicinal plant 

分 类 号：R965[医药卫生—药理学]