Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress  

作　　者：ZHU Ying-Li WANG Lin-Yuan ZHAO Dan-Ping WANG Cheng-Long ZHANG Rui FEI Wen-Ting WANG Jing-Xia ZHANG Jian-Jun 

机构地区：[1]School of Chinese Materia Medica,Bejing University of Chinese Medicine,Bejing,100029,China [2]School of Traditional Chinese Medicine,Bejing University of Chinese Medicine,Beijing,100029,China

出　　处：《Chinese Journal of Natural Medicines》2020年第11期872-880,共9页中国天然药物（英文版）

基　　金：supported by the National Nature Science Foundation of China (Nos. 81473370 and 81173569)。

摘　　要：The depressant-like effects of albiflorin(AF) were studied on stressed chronic restraint stress(CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan(5-HT), 5-hydroxyindoleacetic acid(5-HIAA),noradrenaline(NE) and dopamine(DA) in the hippocampus and increased the level of brain-derived neurotrophic factor(BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal(HPA) cascade,reduced the level of NO and c GMP in serum and inhibited the overexpression of 5-HT2AR m RNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like behaviors.These physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.

关 键 词：Paeonia lactiflora ALBIFLORIN Chronic restraint stress ANTI-STRESS NO-mediated pathway 

分 类 号：R965[医药卫生—药理学]