基于网络药理学探讨麦冬对心脑血管疾病的潜在药理作用靶点  

Exploration of Pharmacological Targets of Ophiopogon in the Treatment of Cardio-cerebral Vascular Diseases Based on Network Pharmacology

作　　者：廖禹程 孙莲[2] 翁琰 王文军 杨倩 丁一 文爱东 Liao Yucheng;Sun Lian;Weng Yan;Wang Wenjun;Yang Qian;Ding Yi;Wen Aidong(Department of Pharmacy,The First Af-filiated Hospital of Air Force Military Medical University,Xi’an 710032,China;School of Pharmacy,Xinjiang Medical University)

机构地区：[1]空军军医大学第一附属医院药剂科,西安710032 [2]新疆医科大学药学院

出　　处：《中国药师》2020年第12期2301-2305,2316,共6页China Pharmacist

基　　金：国家自然科学基金项目(编号:81803749);陕西省重点研发计划社会发展项目(编号:2019SF-118)。

摘　　要：目的:基于网络药理学方法来探讨麦冬对心脑血管疾病(CCVDs)的潜在药理作用靶点。方法:麦冬的化学成分及其靶标基因通过BATMAN-TCM数据库获取,心脑血管疾病靶标基因通过TTD、NCBI和OMIM数据库获取。利用Cytoscape创建麦冬中化合物-靶基因和CCVDs化合物-共有基因靶网络,利用STRING和DAVID分析关键靶标和途径富集。结果:网络分析确定了麦冬中17种化合物以及36个靶标基因与CCVDs高度关联,蛋白互作网络中的核心基因是APOE、LEP、CAT、EDN1和DRD2,并确定了与CCVDs相关的神经活性配体-受体相互作用、醛固酮调节钠的重吸收和脂肪酸降解等核心通路。结论:本研究初步探讨了麦冬的药理作用靶点,以及这些靶点与CCVDs治疗作用的相互关系。Objective: To explore the potential pharmacological targets of ophiopogon in the treatment of cardio-cerebral vascular diseases( CCVDs) based on network pharmacological methods. Methods: The chemical components of ophiopogon and its target genes were obtained through the BATMAN-TCM database,and target genes for cardio-cerebral vascular diseases were obtained through the TTD,NCBI and OMIM databases. Cytoscape was used to create compounds-target genes and CCVDs compounds-shared gene target networks in ophiopogon,and STRING and DAVID were used to analyze key targets and pathway enrichment. Results: Network analysis identified 17 compounds and 36 target genes in ophiopogon highly correlating with CCVDs. The core genes in the protein interaction network were APOE,LEP,CAT,EDN1 and DRD2. The core pathways such as neuroactive ligand-receptor interaction,aldosterone-regulated sodium reabsorption and fatty acid degradation were closely related to CCVDs. Conclusion: This study preliminarily explored the pharmacological targets of ophiopogon and the relationship between the targets and the therapeutic effects of CCVDs.

关 键 词：麦冬 心脑血管疾病 网络药理学 复合靶基因网络 

分 类 号：R285.5[医药卫生—中药学]