应重视对新型冠状病毒肺炎患者活性维生素D的应用  

The importance of the application of active vitamin D in patients with COVID-19 should be emphasized

作　　者：李红涛[1] 汤绍芳[2] Li Hongtao;Tang Shaofang(Department of The First Internal Medicine,Tianjin Corps Hospital of PAPF,Tianjin 300162,China;Department of Endocrinology,The General Hospital of Tianjin Medical University,Tianjin 300052,China)

机构地区：[1]武警天津总队医院内一科,300162 [2]天津医科大学总医院内分泌科,300052

出　　处：《国际内分泌代谢杂志》2020年第6期386-390,共5页International Journal of Endocrinology and Metabolism

摘　　要：新型冠状病毒肺炎(COVID-19)在全球快速蔓延,人群普遍易感。目前认为病毒感染后诱发的免疫、炎性反应及其引起的"细胞因子风暴"是造成患者肺损伤,导致病情危重和死亡的重要原因。既往研究发现,肺感染患者往往存在维生素D不足和血钙降低。活性维生素D除调节钙、磷代谢外,还与机体的防御、炎性反应、免疫调节和修复等病理生理过程密切相关,在预防和治疗肺感染,特别是病毒感染中具有重要作用,且无糖皮质激素的不良反应,不增加病毒复制和继发细菌感染。活性维生素D还能预防和治疗COVID-19康复中可能出现的骨坏死和肺纤维化等并发症。因此,应重视活性维生素D在COVID-19临床诊治中的应用。The COVID-19 is spreading rapidly around the world,and the population is generally easy to be infected.At present,it is believed that the immune,inflammatory reaction and the"cytokine storm"induced by the virus infection are the important causes of the lung damage,which cause patients to get worse and death.Previous studies have found that patients with lung infections often have vitamin D deficiency and low blood calcium.Except regulating of calcium and phosphorus metabolism,the active vitamin D is also closely related to body′s defense,inflammatory response,immune regulation and other pathophysiology processes.It plays an important role in the prevention and treatment of lung infections,especially for the virus infection.The side effects of glucocorticoid increase the viral replication and secondary bacterial infection.The active vitamin D can also prevent and treat the complications such as osteonecrosis and pulmonary fibrosis that may occur during COVID-19 rehabilitation.Therefore,the importance of the application of the active vitamin D in patients with COVID-19 should be emphasized.

关 键 词：新型冠状病毒 新型冠状病毒肺炎 维生素D 免疫 炎症 

分 类 号：R563.1[医药卫生—呼吸系统]