西宁地区HPV不同亚型与女性外阴尖锐湿疣复发的相关性  

Correlation between different subtypes of HPV and recurrence of female genital warts in Xining

作　　者：谢德芳 宋荣花 XIE Defang;SONG Ronghua(Department of Obstetrics and Gynecology,Fourth People's Hospital of Qinghai Province,Xining 810000,Qinghai,China;General Practice,Chaoyang Community Health Service Center,Chengbei Dis­trict,Xining 810001,Qinghai,China)

机构地区：[1]青海省第四人民医院妇产科,西宁810000 [2]西宁市城北区朝阳社区卫生服务中心全科,西宁810001

出　　处：《中国性科学》2020年第12期125-128,共4页Chinese Journal of Human Sexuality

摘　　要：目的探究人乳头瘤病毒(HPV)不同亚型与女性外阴尖锐湿疣(CA)复发的关系。方法选取2016年4月至2018年4月青海省第四人民医院诊治的297例西宁地区女性外阴CA患者作为研究对象。所有患者均接受二氧化碳激光烧灼疣体术,术后联合咪喹莫特乳膏治疗。治疗前后检测外周血中雌二醇(E2)、孕酮(P)、睾酮(T)水平。术后收集疣体样本并通过PCR-膜杂交法检测患者样本中HPV亚型。随访1年以上确定复发情况。比较复发和未复发患者的HPV感染情况,并分析不同HPV亚型与女性外阴CA复发的关系。结果284例患者复发率为37.32%(106例),高危型占79.93%,低危型占20.07%。106例复发患者中,高危型占75.47%,低危型占24.53%。高危型患者E2、P水平高于低危型,CA复发率高于低危型,差异具有统计学意义(P<0.05)。治疗前和治疗3个月后,复发高危型患者的E2和P水平均显著高于复发低危型,差异具有统计学意义(P<0.05),而T水平差异无统计学意义(P>0.05)。结论不同亚型的HPV感染可能具有不同的复发风险,高危型HPV、高E2和P水平的女性外阴CA患者具有更高的复发率。Objective To explore the relationship between different subtypes of human papillomavirus(HPV)and the recurrence of female vulva condyloma acuminatum(CA).Methods A total of 297 female vulva CA patients in Xining treated by the Fourth People′s Hospital of Qinghai Province from April 2016 to April 2018 were selected as the research objects.All patients received underwent CO2 laser wart burn surgery and imiquimod cream treatment after surgery.The levels of estradiol(E2),progesterone(P)and testosterone(T)in peripheral blood were measured before and after treatment.After the operation,the wart body samples were collected and the HPV subtypes in the samples of the research group were detected by PCR-membrane hybridization.Follow up for more than 1 year was to determine the recurrence.HPV infection in patients with and without recurrence was compared,and the relationship between different HPV subtypes and female vulvar CA recurrence was analyzed.Results The recurrence rate of 284 patients was 37.32%(106 cases),high-risk type was 79.93%,low-risk type was 20.07%.Among the 106 recurrent patients,the high-risk type accounted for 75.47%and the low-risk type accounted for 24.53%.The E2 and P levels of high-risk patients were higher than those of low-risk patients,and the CA recurrence rate was higher than that of low-risk patients,with statistically significant differences(P<0.05).Before and 3 months after treatment,E2 and P levels of patients with high-risk of recurrence were significantly higher than those with low-risk of recurrence(P<0.05),while T levels were not statistically significant(P>0.05).Conclusions Different subtypes of HPV infection may have different recurrence risks,and female vulva CA patients with high-risk HPV,high E2 and P levels have a higher recurrence rate.

关 键 词：尖锐湿疣 人乳头瘤病毒 复发 

分 类 号：R759[医药卫生—皮肤病学与性病学]