针灸康复疗法联合关节镜膝关节清理术对膝骨性关节炎患者血清IGF-1、TGF-β及FGF-2水平的影响  

Effect of Acupuncture and Rehabilitation Combined with Arthroscopic Knee Dissection on Serum Levels of IGF-1,TGF-β and FGF-2 in Patients with Knee Osteoarthritis

作　　者：陈焜 杨立东 韩正峰 王国栋[3] CHEN Kun;YANG Li-Dong;HAN Zheng-Feng;WANG Guo-Dong(Beijing Chaoyang District Emergency Medical Rescue Center,Beijing 100026;Chui Yang Liu Hospital Affiliated to Tsinghua University,Beijing 10002;Beijing Tongren Hospital Affiliated to Capital Medical University,Beijing 100730,China)

机构地区：[1]北京市朝阳区紧急医疗救援中心站,北京100026 [2]清华大学附属北京垂杨柳医院,北京100022 [3]首都医科大学附属北京同仁医院,北京100730

出　　处：《生物技术通讯》2020年第5期576-579,共4页Letters in Biotechnology

基　　金：北京市朝阳区科技计划(SF1009,SF1110)。

摘　　要：目的:探讨针灸康复疗法联合关节镜膝关节清理术对膝骨性关节炎患者血清胰岛素样生长因子1(IGF-1)、转化生长因子β(TGF-β)和成纤维细胞生长因子2(FGF-2)水平的影响。方法:选取2018年4月至2019年5月首都医科大学附属北京同仁医院收治的膝骨性关节炎患者94例,依据不同治疗方式分2组,对照组应用关节镜膝关节清理术,研究组联合应用针灸康复疗法,比较2组Lysholm膝关节评分差异及变化,治疗前、后血清FGF-2、IGF-1及TGF-β水平差异及变化。结果:治疗后,研究组Lysholm膝关节评分均显著低于对照组(P<0.05);研究组血清FGF-2、IGF-1及TGF-β水平显著高于对照组(P<0.05)。结论:给予膝骨性关节炎患者使用关节镜下膝关节清理术联合针灸康复疗法,可显著提高患者的血清FGF-2、IGF-1及TGF-β水平。Objective:To investigate the effect of acupuncture and rehabilitation therapy combined with arthroscopic knee arthroscopy on serum levels of insulin-like growth factor-1(IGF-1), fibroblast growth factor-2(FGF-2) and transforming growth factor-β(TGF-β) in patients with knee osteoarthritis.Methods:94 patients with knee osteoarthritis admitted to Beijing Tongren Hospital Affiliated to Capital Medical University from April2018 to May 2019 were selected. They were divided into two groups according to different treatment methods. The differences and changes of Lysholm knee score between the two groups were compared. Differences and changes in serum FGF-2, IGF-1 and TGF-β levels before and after treatment were analyzed.Results:After treatment,Lysholm knee score in the study group was significantly lower than that in the control group(P<0.05). Serum FGF-2, IGF-1 and TGF-β levels in the study group were significantly higher than those in the control group(P<0.05).Conclusion:Serum FGF-2, IGF-1 and TGF-β levels in patients with knee osteoarthritis were significantly increased by arthroscopic knee clearance combined with acupuncture and rehabilitation therapy.

关 键 词：膝骨性关节炎 针灸康复疗法 关节镜膝关节清理术 胰岛素样生长因子1(IGF-1) 转化生长因子β(TGF-β) 成纤维细胞生长因子2(FGF-2) 

分 类 号：R684[医药卫生—骨科学]