盐酸羟考酮超前镇痛对腹式全子宫切除术者炎性因子、NRS评分、皮质醇水平及免疫功能影响  

Effects of oxycodone hydrochloride for preemptive analgesic on the inflammatory factors,NRS score,cortisol level,and immune function of patients with abdominal hysterectomy

作　　者：曹妍 应颖 陈清娟 CAO Yan;YING Ying;CHEN Qingjuan(Enze Hospital of Enze Medical Center (Group), Taizhou, Zhejiang Province, 318050)

机构地区：[1]浙江省台州恩泽医疗中心(集团)恩泽医院,318050

出　　处：《中国计划生育学杂志》2020年第11期1782-1785,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨盐酸羟考酮超前镇痛对腹式全子宫切除术患者炎性因子、NRS评分、皮质醇水平及免疫功能的影响。方法:选取2016年10月—2019年9月本院行腹式全子宫切除术患者76例,随机分为对照组和观察组各38例。麻醉诱导前15min,对照组患者静脉推注0.9%氯化钠注射液10 ml,观察组患者静脉推注盐酸羟考酮注射液0.1 mg/kg,其他过程一致。比较两组手术时间、术中出血量以及麻醉诱导前15min、术后12h、术后24h时炎性因子水平、疼痛数字评分法(NRS)评分、皮质醇水平以及免疫功能。结果:两组手术时间(67.5±9.4 min、64.8±7.3 min)和术中出血量(105.6±14.1ml、108.5±16.4ml)无差异(P>0.05);术后12h、24h两组炎性因子和皮质醇水平及NRS评分均升高,但观察组均低于对照组(P<0.05);两组免疫功能指标均降低,但观察组均高于对照组(P<0.05)。结论:盐酸羟考酮超前镇痛可显著降低手术患者的炎性因子和皮质醇水平、缓解术后疼痛,有利于患者术后免疫功能恢复。Objective:To investigate the effect of oxycodone hydrochloride for preemptive analgesic on the inflammatory factors,NRS score,cortisol level,and immune function of patients with abdominal hysterectomy.Methods:From October 2016 to September 2019,76 patients who underwent abdominal hysterectomy were selected and were randomly divided into control group and study group(38 cases in each group).15 minutes before the induction of anesthesia,the patients in the control group were intravenously injected with 10 mL of 0.9%sodium chloride injection,and the patients in the study group were intravenously injected with 0.1 mg/kg of oxycodone hydrochloride injection.The other treatment for patients in the two groups was similar.The operation time and blood loss,intraoperative bleeding volume,and the levels of inflammatory factors,NRS,and cortisol,and immune function 15 minutes before anesthesia,12 hours after anesthesia,and 24 hours after anesthesia of patients were compared between the two groups.Results:There were no significant different in operation time(67.5±9.4 min vs.64.8±7.3 min)and blood loss(105.6±14.1ml vs.108.5±16.4ml)of patients between the two groups(P>0.05).At 12 hours and 24 hours after surgery,the levels of inflammatory factors and cortisol,as well as the NRS scores of patients in the two groups had increased significantly,but those of patients in the study group were significant lower than those of patients in the control group(P<0.05).At 12 hours and 24 hours after surgery,the levels of the immune function indexes of patients in the two groups had decreased significantly,but those of patients in the study group were significant higher than those of patients in the control group(P<0.05).Conclusion:Oxycodone hydrochloride for preemptive analgesia of patients with abdominal hysterectomy can significantly reduce their levels of inflammatory factors and cortisol,can relieve their postoperative pain,which is conducive to the recovery of postoperative immune function of patients.

关 键 词：腹式全子宫切除术 超前镇痛 盐酸羟考酮 炎症 免疫功能 

分 类 号：R47[医药卫生—护理学]