丹栀逍遥片治疗PCOS排卵功能障碍性不孕症疗效及对卵巢功能及妊娠结局影响  

Clinical efficacy of Danzhi xiaoyao tablets for treating infertile women with dysfunctional ovulatory by PCOS,and its influence on their pregnancy outcomes

作　　者：施跃先 任慧君 李莉[1] 李茜[1] 向琼瑶 SHI Yuexian;REN Huijun;LI Li;LI Xi;XIANG Qiongyao(The Third People's Hospital of Chengdu City, Sichuan Province, 610031)

机构地区：[1]四川省成都市第三人民医院,610031

出　　处：《中国计划生育学杂志》2020年第11期1840-1843,共4页Chinese Journal of Family Planning

摘　　要：目的:分析丹栀逍遥片治疗多囊卵巢综合征(PCOS)排卵功能障碍性不孕症临床疗效以及对患者卵巢功能和妊娠结局的影响。方法:回顾性收集2016年1月—2019年1月在本院收治的120例PCOS排卵功能障碍性不孕症患者临床资料。根据治疗方式不同分为对照组48例(常规西医治疗)和观察组72例(常规西医治疗+丹栀逍遥片治疗)。对比两组患者治疗前后性激素变化情况、卵巢功能、妊娠结局以及不良反应。结果:治疗后两组性激素水平均有所改善,且观察组雌二醇(279.86±37.89 pgl/ml)高于对照组(255.26±35.33 pgl/ml),睾酮(2.33±0.87 pmol/ml)、卵泡刺激素(5.21±0.88 mlu/ml)、黄体生成素(11.48±1.46 mlu/ml)均低于对照组;两组卵巢均有所改善,且观察组优势卵泡个数、优势卵泡直径均优于对照组,卵泡期(8.93±0.45mm)、黄体期子宫内膜厚度(12.38±0.46mm)大于对照组(P<0.05);治疗后观察组A型子宫内膜占比(69.4%)高于对照组(31.3%)(P<0.05);观察组妊娠率(55.6%)高于对照组(35.4%)(P<0.05),流产率两组无差异(P>0.05);不良反应总发生率观察组(2.8%)与对照组(2.1%)无差异(P>0.05)。结论:常规西医结合丹栀逍遥片治疗PCOS排卵功能障碍性不孕症临床疗效显著,可更好地改善患者性激素水平,提高排卵率和妊娠率,且安全性较好。Objective:To analyze the clinical efficacy of Danzhi xiaoyao tablets for treating infertile women with dysfunctional ovulatory by polycystic ovary syndrome(PCOS),and to study its influence on their pregnancy outcomes.Methods:The clinical data of 120 infertile women with dysfunctional ovulatory by PCOS from January 2016 to January 2019 were analyzed retrospectively.According to different treatment,these women were divided into 48 cases in the control group(women with conventional western medicine treatment)and 72 cases in the observation group(women with conventional Western medicine treatment combined with Danzhi Xiaoyao tablet).The sex hormone levels changes,ovarian function,pregnancy outcomes,and adverse reactions of women before and after treatment were compared between the two groups.Results:After treatment,the levels of sex hormones of women in the two groups had increased significantly(P<0.05),the E2 level of women in the observation group(279.86±37.89 pgl/ml)was significant higher than that(255.26±35.33 pgl/ml)of women in the control group,but the levels of T(2.33±0.87 pmol/ml),FSH(5.21±0.88 mlu/ml),and LH(11.48±1.46 mlu/ml)of women in the observation group were significant lower.After treatment,the ovarian condition of women in both groups had improved significantly(P<0.05),the number of dominant follicles and the diameter of the dominant follicles of women in the observation group were significant better than those of women in the control group.After treatment,the diameter of follicles(8.93±0.45mm)and endometrial thickness in luteal stage(12.38±0.46mm)of women in the observation group were significant higher than those of women in the control group.After treatment,the proportion of endometrium in type A(69.4%)and the pregnancy rate(55.6%)of women in the observation group were significant higher than those(31.3%and 35.4%)of women in the control group(P<0.05).There was no significant difference in the miscarriage rate of women between the two groups(P>0.05),and the total incidence of adverse reactio

关 键 词：PCOS排卵功能障碍性不孕症 丹栀逍遥片 临床疗效 卵巢功能 妊娠结局 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]