改良自然周期方案对卵巢储备功能低下患者临床疗效  

Clinical efficacy of modified naturalcycle for treating women with ovarian reserve dysfunction

作　　者：王春利 徐洁 WANG Chunli;XU Jie(Northwest Women's and Children's Hospital, Xian City, Shaanxi Province, 710003)

机构地区：[1]西北妇女儿童医院生殖中心,西安710003

出　　处：《中国计划生育学杂志》2020年第11期1864-1867,共4页Chinese Journal of Family Planning

摘　　要：目的:分析改良自然周期方案对卵巢储备功能低下患者的临床疗效。方法:回顾性分析2018年6月-2020年1月于本院行体外受精-胚胎移植助孕的85例卵巢储备功能低下患者临床资料,根据助孕方案分为改良自然周期组、高孕激素下促排卵组及微刺激组。记录3组方案启动前患者基础性激素水平、治疗情况及临床结局。结果:3组方案启动前各组基础性激素水平无差异(P>0.05)。改良自然周期方案组HCG日雌二醇、获卵数及可利用胚胎数均低于另外两组,HCG日黄体生成素(LH)最高值、未获卵率均高于另外两组(P<0.05);改良自然周期方案组单周期临床妊娠率(8.7%)与另外两组(6.3%、8.0%)无差异,累积临床妊娠率(20.0%)与另外两组(17.9%、24.3%)也无差异(均P>0.05)。结论:卵巢储备功能低下患者采取改良自然周期方案,尽管周期取消率高、获卵率低,但具有操作简单经济等优势,临床妊娠率相对满意,但需要临床把握好取卵时机。Objective:To analyze the clinical efficacy of modified natural cycle for treating women with ovarian reserve dysfunction.Methods:The clinical data of 89 women with ovarian reserve dysfunction were analyzed retrospectively.According to assisted reproductive protocol,these women were divided into three group,which included women accepted the modified natural cycle in group A,women accepted the ovulation induction in high level of progestational hormone in group B,and women accepted the micro stimulation in group C.The levels of basic sex hormones,treatment-related conditions,and clinical outcomes of women in the three groups were recorded.Results:There were no significant difference in the levels of basic sex hormones of women among the three groups before the start of the protocol(P>0.05).The E2 level on the HCG day,the number of oocytes obtained,and the number of usable embryos of women in group A were significant lower than those of women in the other two groups,but the LH level and the highest LH level on the HCG day and the rate of no oocytes obtained of women in group A were significant higher than those in the other two groups(P<0.05).The single cycle clinical pregnancy rate(8.7%)of women in group A had no significant different from that(6.3%)of women in group B and that(8.0%)of women in C.The accumulated clinical pregnancy rate(20.0%)of women in group A had no significant different from that(17.9%)of women in group B and that(24.3%)of women in C(all P>0.05).Conclusion:The modified natural cycle scheme can be used for women with poor ovarian reserve function,although the cycle cancellation rate of which is high and the egg acquisition rate of which is low,it has advantages such as simple operation and economy,and the clinical pregnancy rate is relatively satisfactory.However,it was necessary to grasp the timing of egg obtaining in clinical practice.

关 键 词：卵巢储备功能低下 人工助孕 改良自然周期 临床妊娠率 取卵时机 

分 类 号：R714.8[医药卫生—妇产科学]