老年原发性骨质疏松症患者血清25-羟维生素D水平检测及与骨代谢指标的相关性分析  

Detection of Level of Serum 25-hydroxyvitamin D Level in Elderly Patients with Primary Osteoporosis and Its Correlation with Bone Metabolism

作　　者：王立敏[1] 刘淘真[1] 朱路 邓毅[1] 帅婧[1] 黄因子 WANG Li-min;LIU Tao-zhen;ZHU Lu;DENG Yi;SHUAI Jing;HUANG Yin-zi(Department of Geriatrics,The First People's Hospital of Guiyang,Guiyang,Guizhou,550002,China)

机构地区：[1]贵阳市第一人民医院老年医学科,贵州贵阳550002

出　　处：《现代生物医学进展》2020年第19期3749-3752,3744,共5页Progress in Modern Biomedicine

基　　金：贵州省科学技术基金项目(黔科合J字[2013]2018号)。

摘　　要：目的:检测并分析老年原发性骨质疏松症患者血清25-羟维生素D[25-(OH)D]水平及其与骨代谢指标的相关性。方法:选取2013年4月到2019年5月期间在我院接受治疗的老年原发性骨质疏松症患者166例作为骨质疏松组,另选取同期在我院进行体检的无骨质疏松老年人群117例作为无骨质疏松组。检测所有研究对象的血清25-(OH)D、I型胶原氨基酸延长肽(PINP)、β-胶原特殊序列(β-CTX)、N-端骨钙素(N-MID)的水平,并分析血清25-(OH)D与骨代谢指标的相关性。结果:166例老年原发性骨质疏松症患者的血清25-(OH)D水平为(16.82±4.52)ng/mL,其中维生素D缺乏64例、占38.56%,维生素D不足72例、占43.37%,维生素D正常30例,占18.07%。不同性别的老年原发性骨质疏松症患者的血清25-(OH)D水平比较差异无统计学意义(P>0.05),不同性别的老年原发性骨质疏松症患者的维生素D缺乏、不足、正常占比比较差异无统计学意义(P>0.05)。骨质疏松组血清25-(OH)D水平明显低于无骨质疏松组(P<0.05),骨质疏松组血清β-CTX水平明显高于无骨质疏松组(P<0.05),骨质疏松组和无骨质疏松组的血清PINP、N-MID水平比较差异无统计学意义(P>0.05)。经Pearson相关分析显示,老年原发性骨质疏松症患者的血清25-(OH)D与β-CTX呈负相关(P<0.05),与PINP、N-MID无明显的相关性(P>0.05)。结论:老年原发性骨质疏松症患者存在明显的维生素D缺乏、不足,但无明显的性别差异,血清25-(OH)D与β-CTX呈负相关,联合检测血清25-(OH)D和β-CTX有助于老年原发性骨质疏松症的早期诊断和治疗。Objective:To detecte and analysis of level of serum 25-hydroxyvitamin D(25-(OH)D)in elderly patients with primary osteoporosis and its correlation with bone metabolism.Methods:166 elderly patients with primary osteoporosis who were treated in our hospital from April 2013 to May 2019 were selected as the osteoporosis group,and 117 without osteoporosis elderly people who underwent physical examination in our hospital during the same period were selected as the non-osteoporosis group.The levels of serum 25-(OH)D,I-collagen amino-terminal extension of the peptide(PINP),β-collagen specific sequences(β-CTX)and N-terminal osteocalcin(N-MID)were measured in all subjects.The correlation between serum 25-(OH)D and bone metabolism indicators was analyzed.Results:The level of serum 25-(OH)D of 166 elderly patients with primary osteoporosis was(16.82±4.52)ng/mL,of which 64 cases were deficient,accounting for 38.55%;less than 72 cases,accounting for 43.37%;and 30 cases were normal,accounting for 18.07%.There was no significant difference in level of serum Vitamin D between different genders in patients with primary osteoporosis(P>0.05).There was no significant difference in Vitamin D deficiency,insufficient and normal proportion between different genders in patients with primary osteoporosis(P>0.05).The level of serum 25-(OH)D in osteoporosis group was significantly lower than that in non-osteoporosis group(P<0.05).The level of serumβ-CTX in osteoporosis group was significantly higher than that in non-osteoporosis group(P<0.05).There were no significant differences in levels of serum PINP and N-MIDbetween osteoporosis group and non-osteoporosis group(P>0.05).Pearson analysis showed that serum 25-(OH)D was negatively correlated withβ-CTX in elderly patients with primary osteoporosis(P<0.05),but it was not with PINP and N-MID(P>0.05).Conclusion:There are obvious vitamin D deficiency and insufficient in elderly patients with primary osteoporosis,but there is no significant gender difference.Serum 25-(OH)D is negatively corre

关 键 词：原发性骨质疏松症 维生素D 25-羟维生素D 骨代谢 老年 

分 类 号：R68[医药卫生—骨科学] Q565[医药卫生—外科学]