GSH响应型MS基药物释放体系的构建及性能研究  

Study on the Construction and Properties of Glutathione-responsive Mesoporous Silica-based Drug Release System

作　　者：滕鑫[1] 赵文茹[1] 唐颂超[1] 钱军[1] 徐世爱[1] 庄启昕[1] TENG Xin;ZHAO Wenru;TANG Songchao;QIAN Jun;XU Shiai;ZHUANG Qixin(National Material Experimental Teaching Demonstration Center,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学国家级材料实验教学示范中心,上海200237

出　　处：《实验科学与技术》2020年第6期1-7,共7页Experiment Science and Technology

基　　金：上海市实验队伍建设2018专项经费。

摘　　要：该文利用生物体内肿瘤部位还原型谷胱甘肽(GSH)含量较高的特点,设计了一种新型的GSH响应型的表面具有二硫键的胱胺二盐酸盐修饰的介孔二氧化硅纳米粒子(MSN)。通过胱胺二盐酸盐上的氨基与戊二醛的席夫碱反应实现介孔孔道的封装,再通过GSH对二硫键的断裂作用实现药物的控释。同时,以布洛芬(IBU)和阿霉素盐酸盐(DOX)作为模型药物,测定了模型药物在载体材料中的装载量,研究了GSH浓度对模型药物释放效率的影响,及载体材料的生物相容性。研究结果表明,模型药物的释放量与GSH的浓度呈正相关性,功能化的MSN具有良好的生物相容性和被吞噬能力。In light of the high level of glutathione(GSH)in tumors,the study designed and prepared a novel glutathione(GSH)-responsive mesoporous silica nanoparticle(MSN)modified with cystamine dihydrochloride.The blockage of channels on the surfaces of MSN was achieved by the Schiff base reaction between amino groups in cystamine dihydrochloride and glutaraldehyde.The triggered release of drug was achieved by the cleavage of disulfide bond.Meanwhile,ibuprofen(IBU)and doxorubicin hydrochloride(DOX)were chosen as the model drugs to measure the loading capacity of the carrier and study the biocompatibility of carrier.Results showed that the release amount of the model drugs were well correlated with GSH concentration,and the functionalized MSN had good biocompatibility and phagocytosis ability.

关 键 词：介孔二氧化硅 谷胱甘肽 表面功能化 药物释放体系 

分 类 号：TQ460.4[化学工程—制药化工]