2014—2018年宝鸡市肾综合征出血热宿主动物监测分析  

Survey on host animals of hemorrhagic fever with renal syndrome in Baoji City of Shaanxi Province from 2014 to 2018

作　　者：李红兵[1] 付海龙[1] 胡侃[1] 胡晓倩[1] 邓峰[1] 张克俭[1] 高娟[1] 严钏元[1] 田辉[1] 张亚宁[1] LI Hong-bing;FU Hai-long;HU Kan;HU Xiao-qian;DENG Feng;ZHANG Ke-jian;GAO Juan;YAN Chuan-yuan;TIAN Hui;ZHANG Ya-ning(Baoji Center for Disease Control and Prevention,Baoji 721006,China)

机构地区：[1]宝鸡市疾病预防控制中心,陕西宝鸡721006

出　　处：《中华卫生杀虫药械》2020年第6期529-532,共4页Chinese Journal of Hygienic Insecticides and Equipments

摘　　要：目的分析2014—2018年宝鸡市肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)宿主动物监测情况,为宝鸡市HFRS防控提供科学依据。方法收集2014—2018年肾综合征出血热发病率;采用夹夜法调查鼠密度,酶联免疫法检测鼠血抗体,使用RT—PCR法进行汉坦病毒检测和基因分型;秩相关统计方法分析宿主动物监测数据与人间HFRS发病关系。结果2014—2018年共捕鼠1240只,属7种。总鼠密度为1.28%,野外鼠密度高于居民区鼠密度(χ^2=85.17,P<0.01),其中野外鼠种以黑线姬鼠和小家鼠为主,居民区以小家鼠为主。鼠血抗体阳性率为33.92%,鼠带毒率为1.84%。2014—2016年带毒宿主均为黑线姬鼠,2018年带毒宿主以黑线姬鼠、小家鼠、褐家鼠、黄毛鼠为主。2018年汉坦病毒分型中6例为汉滩病毒型汉坦病毒,4例为大别山型汉坦病毒。鼠密度与人间HFRS发病呈正相关(r_s=0.900,P=0.037)。结论宝鸡市HFRS宿主主要为黑线姬鼠,疫区为以黑线姬鼠为主的混合型疫区,且出现大别山型基因型,应加大宿主动物监测,及早预测出血热发病。Objective To monitor the host animals of hemorrhagic fever with renal syndrome(HFRS),and provide a basis for control strategies.Methods From 2014 to 2018,the incidence data of HFRS were collected.The night trapping method was adopted to monitor the rodent densities and the enzyme-linked immunoassay was used to detect serum anti-Hantavirus(HV)antibody.The antigen of HV in the rodent lungs and the specific gene fragments of HV nucleic acids in rodent lung tissues were detected with RT-PCR.The correlations of HFRS incidence to monitoring results were analyzed statistically.Results Totally 1240 rodents,belonging to 7 species,were captured from 2014 to 2018.The average rodent density was 1.28%,and the rodent density in field was higher than that of indoors(χ^2=85.17,P<0.01).Apodemus agrarius and Mus musculus were the dominant rodent species in field area,while Mus musculus was the dominant species indoors.The positive rate of antibody in the rodent blood was 33.92%,and the overall positive rate of HV was 1.84%.The main virus carriers were Apodemus agrarius from 2014 to 2016,Apodemus agrarius,Mus musculus,Rattus norvegicus and Rattus losea in 2018.In 2018,6 cases were Hantaan virus and 4 cases were Dabieshan virus.The HFRS incidence was correlated to the rodent density(r_s=0.900,P=0.037).Conclusion Apodemus agrarius was the dominant host animal and a new DBSV type was detected.It was a mixed-type of epidemic area of HFRS in the city of Baoji,so intensified surveillance should be taken to predict HFRS in future.

关 键 词：肾综合征出血热 宿主动物 监测 

分 类 号：R184.3[医药卫生—流行病学] R183.5[医药卫生—公共卫生与预防医学]