多组分超分子药物水凝胶的构建及其用于灭血吸虫尾蚴药物缓释研究  

Construction of Multi Component Supramolecular Drug Hydrogel and Its Sustained-release Drug for Schistosoma Japonicum Cercariae

作　　者：胡小涛 李海龙 谭悦 Hu Xiao-tao;Li Hai-long;Tan Yue(School of Chemistry and Chemical Engineering,Gannan Normal University,Jiangxi Ganzhou 341000;Jiangxi Runze Pharmaceutical Co.,Ltd,Jiangxi Ganzhou 341000)

机构地区：[1]赣南师范大学化学化工学院,江西赣州341000 [2]江西润泽药业有限公司,江西赣州341000

出　　处：《江西化工》2020年第6期49-54,共6页Jiangxi Chemical Industry

摘　　要：制备了一种由氨基酸衍生物(NAAPD)和氧化石墨烯(GO)组成的新型双组分水凝胶,这种水凝胶作为载体负载了抗尾蚴药物。利用扫描电子显微镜(SEM)、X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)和原子力显微镜(AFM)对其进行了表征。实验结果表明该水凝胶具有优异的力学性能和良好的载药能力,其药物缓释时间较长且能有效杀灭血吸虫尾蚴。A new two component hydrogel consisting of amino acid derivative(NAAPD)and graphene oxide(GO)was prepared.The hydrogel was used as a carrier to carry out anti cercariae drugs.They were characterized by scanning electron microscopy(SEM),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR)and atomic force microscopy(AFM).The experimental results show that the hydrogel has excellent mechanical properties and good drug loading ability,and its drug release time is longer and can effectively kill schistosome cercariae.

关 键 词：水凝胶 药物缓释 血吸虫尾蚴 

分 类 号：TQ427.26[化学工程] TQ460.4