O-GIcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis  

作　　者：Fan Yu Te Li Yanchao Sui Qingxia Chen Song Yang Jia Yang Renjie Hong Dengwen Li Xiumin Yan Wei Zhao Xueliang Zhu Jun Zhou 

机构地区：[1]Department of Genetics and Cell Biology,College of Lifle Sciences,State Key Laboratory of Medicinal Chemical Biology,Tanjin Key Laboratory of Protein Science,Key Laboratory of Bioactive Materials of the Ministry of Education,Nankai Universily,Tianjin 300071,China [2]College of Pharmacy,State Key Laboratory of Medicinal Chemical Biology,Nankai Uniyersity,Tianjin 300071,China [3]State Key Laboratory of Cell Biology,Shanghai Insttute of Biochemistry and Cell Biology,Center for Excel lence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China [4]University of Chinese Academy of Sciences,Beijing 100049,China [5]Institute of Biomedical Sciences,Shandong Provincial Key Lab-oratory of Animal Resistance Biology,Collaboralive Innovation Center of Cell Biology in Universities of Shandong,Collge of Life Sciences.Shandong Nomal University,Jinan 250014,China

出　　处：《Protein & Cell》2020年第11期852-857,共6页蛋白质与细胞（英文版）

基　　金：We thank Dr.Wen Ning for providing the Ube-Cre-ERT2 mice.This work was supported by grants from the National Key R&D Program of China(2017YFA0503502);the National Natural Science Foundation of China(31991193).Fan Yu,Te Li。Yanchao Sui,Qingxia Chen,Song Yang,Jia Yang,Renjie Hong,Dengwen they have no conflict of interest.All institutional and national guidelines for the care and use of laboratory animals were fllowed.Li,Xiumin Yan,Wei Zhao,Xueliang Zhu,and Jun Zhou declare that。

摘　　要：Dear Editor,O-GIcNAcylation is a nutrient sensor that is particularly sensitive to environmental glucose(Hardiville and Hart,2014).Glucose can be converted to UDP-GIcNAc through the hexosamine biosynthetic pathway,providing a substrate for O-GIcNAcylation.Two enzymes participate in this reversible modification,O-GIcNAc transferase(OGT),which adds a single GIcNAc residue to the serine/threonine sites of proteins,and O-GIcNAcase(OGA),which removes the residue(Yang and Qian,2017).

关 键 词：UDP RESIDUE REMOVE 

分 类 号：Q2[生物学—细胞生物学]