P2受体介导的ATP诱导胞内Ca^2+增加引起的细胞迁移及相关信号通路  

Cell migration caused by increased intracellular Ca^2+induced by ATP via P2 receptor and related signaling pathways

作　　者：崔艺琴(综述) 杨艳(审校) CUI Yiqin;YANG Yan(Institute of Cardiovascular Research of Southwest Medical University,Key Laboratory of Medical Electrophysiology of Ministry of Education,Medical Electrophysiology Key Laboratory of Sichuan Province,Luzhou 646000,Sichuan Province,China)

机构地区：[1]西南医科大学心血管医学研究所·医学电生理学教育部重点实验室,医学电生理四川省重点实验室,四川泸州646000

出　　处：《西南医科大学学报》2020年第6期628-633,共6页Journal of Southwest Medical University

基　　金：国家自然科学基金项目(31972909,81173661);四川省心血管疾病防治协同创新中心资助项目(xtcx2019-09);四川省国际科技创新合作项目(2019YFH0174)。

摘　　要：细胞迁移在伤口愈合、癌细胞侵袭等生理病理过程中发挥主要作用。细胞迁移是指细胞在接受迁移信号或者感受到某些物质的梯度后产生的移动。越来越多的研究表明,胞外ATP通过激活细胞膜上的P2受体促使细胞内Ca^2+浓度增加,构成了ATP-Ca^2+信号机制,影响细胞功能。胞内Ca^2+是机体包括细胞迁移等多种生理过程的主要第二信使,可通过调控Ca^2+依赖性相关信号通路产生细胞迁移作用。本文综述近年来关于参与ATP诱导细胞内Ca^2+浓度增加作用中P2受体的研究,讨论ATP引起胞内Ca2+增加导致的细胞迁移以及参与调控的相关信号通路,为相关疾病的治疗提供新的靶点和方法。Cell migration plays an important role in the physiological and pathological processes including wound healing and cancer cell invasion.Cell migration refers to the movement of cells after they receive migration signals or feel the gradient of certain substances.More and more studies have shown that extracellular adenosine triphosphate(ATP)promotes the increase in intracellular Ca^2+concentration by activating P2 receptors on cell membrane,which constitutes the ATP-Ca^2+signaling mechanism and affects cell function.Intracellular Ca2+is the main second messenger of many physiological processes in the body,including cell migration,and it can induce cell migration by regulating Ca^2+-dependent signaling pathways.This article reviews the recent studies on P2 receptors involved in ATP induction of increased intracellular Ca^2+concentration and discusses cell migration caused by increased intracellular Ca2+and related signaling pathways involved in regulation,so as to provide new targets and methods for the treatment of related diseases.

关 键 词：P2受体 ATP 胞内Ca2+ 细胞迁移 

分 类 号：R657.3[医药卫生—外科学]