冠心病患者血清HN、CTRP3与血脂及病情严重程度的关系研究  

Studies on the Relationship between Serum HN, CTRP3 and Blood Lipid,Severity of Illness in Patients with Coronary Heart Disease

作　　者：雷肖蠢 倪宁[2] 李鑫[1] 朱玉江[1] 邱军杰[1] LEI Xiao-chun;NI Ning;LI Xin;ZHU Yu-jiang;QIU Jun-jie(Department of Internal Medicine Cardiovascular,The Second Affiliated Hospital of Xi'an Medical University,Xi'an,Shaanxi,710038,China;Department of Internal Medicine,Xi'an Jiaotong University Hospital,Xi'an,Shaanxi,710049,China)

机构地区：[1]西安医学院第二附属医院心血管内科,陕西西安710038 [2]西安交通大学医院内科,陕西西安710049

出　　处：《现代生物医学进展》2020年第21期4134-4138,共5页Progress in Modern Biomedicine

基　　金：陕西省社会发展攻关计划项目(2015K130221)。

摘　　要：目的:分析血清抗凋亡多肽(HN)、补体C1q肿瘤坏死因子相关蛋白因子3(CTRP3)与冠心病(CHD)患者血脂及病情严重程度的关系。方法:选取2017年1月至2018年12月期间西安医学院第二附属医院收治的CHD患者360例(CHD组),另选取同期健康体检者100例作为对照组(NC组),比较两组血清HN、CTRP3、血脂水平及基线资料;根据CHD患者病变支数分为单支病变组(n=131)、双支病变组(n=119)、多支病变组(n=110),根据冠状动脉造影结果测定Gensini积分,采用Pearson相关分析HN、CTRP3与血脂及Gensini积分的相关性。结果:CHD组患者吸烟史比例、收缩压、空腹血糖、总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白(LDL-C)水平均高于NC组(P<0.05),血清HN、CTRP3和高密度脂蛋白(HDL-C)均低于NC组(P<0.05);CHD双支病变组和多支病变组患者吸烟史、空腹血糖、TC水平以及Gensini积分均高于单支病变组,CTRP3和HDL-C水平均低于单支病变组,多支病变组收缩压高于单支病变组,多支病变组吸烟史、空腹血糖和Gensini积分均高于双支病变组,且多支病变组CTRP3低于双支病变组(均P<0.05);Pearson相关分析结果显示:CHD患者血清HN水平与HDL-C水平呈正相关性,CHD患者血清CTRP3水平与Gensini积分呈负相关(P<0.05)。结论:CHD患者血清中HN、CTRP3水平均显著降低,HN与HDL-C水平呈正相关,CTRP3降低程度与CHD患者病情严重程度有关,临床可考虑将其作为评估CHD患者病情严重程度的辅助血清学指标。Objective: To analyze the relationship between serum anti-apoptotic polypeptide(HN), C1 q/TNF-related protein 3(CTRP3) and blood lipid and severity of illness in patients with coronary heart disease. Methods: A total of 360 patients with CHD(CHD group) who were admitted to the Second Affiliated Hospital of Xi’an Medical University from January 2017 to December 2018 were selected, and 100 healthy subjects in the same period were selected as healthy control group(NC group), the serum HN, CTRP3, blood lipid and baseline data were compared between the two groups. CHD patients were divided into single-vessel lesion group(n=131),double-vessel lesion group(n=119) and multi-vessel lesion group(n=110) according to the number of lesion branches,.Gensini score was measured according to the results of coronary angiography, Pearson correlation analysis was used to analyze the correlation between HN and CTRP3 and blood lipid and Gensini scores. Results: The proportion of smoking history, systolic blood pressure, fasting blood sugar,total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL-C) in CHD group were higher than those in NC group(P<0.05),while serum HN, CTRP3 and high density lipoprotein(HDL-C) were lower than those in NC group(P<0.05);The smoking history,fasting blood glucose, TC level and Gensini score in CHD double-vessel lesion group and multi-vessel lesion group were higher than those in single-vessel lesion group, and CTRP3 and HDL-C levels were lower than those in single-vessel lesion group. Systolic blood pressure in multi-vessel lesion group was higher than that in single-vessel lesion group, the smoking history, fasting blood sugar and Gensini score in multi-vessel lesion group were higher than those in double-vessel lesion group, and CTRP3 in multi-vessel lesion group was lower than that in double-vessel lesion group(all P<0.05). Pearson correlation analysis showed that serum HN level was positively correlated with HDL-C level in patients with CHD, and serum CTRP3 level was negatively correlate

关 键 词：冠心病 抗凋亡多肽 补体C1q肿瘤坏死因子相关蛋白因子3 血脂 GENSINI积分 病情 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]