胰腺移植的现状与展望  

Current status and prospect of pancreas transplantation

作　　者：石宜铭 Yi-Ming Shyr(Department of Surgery,Taipei Veterans General Hospital,Taiwan,China)

机构地区：[1]中国台北荣民总医院普通外科

出　　处：《中华消化外科杂志》2020年第12期1243-1247,共5页Chinese Journal of Digestive Surgery

摘　　要：目前胰腺移植是治疗1型糖尿病最可靠,可实现永久性治疗效果的外科手术。胰腺功能重度障碍导致的血糖水平长期控制不良或重度糖尿病是发生心脏病、中风、尿毒症、失明等疾病的危险因素,患者生命质量通常极差。胰腺移植可使受者血糖浓度恢复正常水平,改善受者糖尿病并发症,包括肾脏病变、神经性病变、视网膜病变等,降低受者的病残率和病死率。笔者结合中国台北荣民总医院临床实践经验,探讨胰腺移植治疗1型糖尿病的手术方式、适应证与禁忌证、供者与受者选择、手术流程与术后并发症、免疫抑制剂及其相关并发症、术后排斥反应及其处理、疗效及预后相关因素,旨在为广大同道提供参考。Pancreas transplantation is currently the most reliable and effective treatment option to cure the type 1 diabetes.Severe dysfunction of pancreas which will lead long⁃term poor control of blood glucose or severe diabetes is a risk factor of heart disease,stroke,uremia,blindness and other diseases,and the quality of life of patients is often very poor.Pancreas transplantation can restore the blood glucose of recipient to normal level,improve the complications of recipient with diabetes,including renal disease,neuropathy,retinopathy,etc.,and reduce the disability and mortality of recipients.Based on the clinical experience of Taipei Veterans General Hospital,the author discussed the surgical types,indications and contraindications,donor and recipient selection,surgical proce⁃dures and postoperative complications,immunosuppressive agents and related complications,postoperative rejection and its management,curative effect and prognosis related factors of pancreas transplantation for type 1 diabetes with the aim to provide references to surgeons.

关 键 词：器官移植 胰腺 1型糖尿病 移植物排斥 经验 

分 类 号：R657.5[医药卫生—外科学]