淋巴细胞亚群、C反应蛋白、降钙素原与分泌性中耳炎复发的关系  

The relationship between lymphocyte subsets,CPR,PCT and recurrence of secretory otitis media

作　　者：王菲[1] 宋翊飒[1] 安晶 甘青[1] Wang Fei;Song Yisa;An Jing;Gan Qing(Qinghai Provincial People’s Hospital,Xining 810007 China)

机构地区：[1]青海省人民医院,青海西宁810007

出　　处：《甘肃医药》2020年第10期865-868,共4页Gansu Medical Journal

摘　　要：目的:观察淋巴细胞亚群、C反应蛋白、降钙素原的改变与分泌性中耳炎复发的关系。方法:回顾性分析2015年1月至2018年12月于我院住院治疗的118例分泌性中耳炎患者的临床资料。根据以前是否患有分泌性中耳炎分为初发组及复发组。比较两组入院时的白细胞计数,C反应蛋白,降钙素原,淋巴细胞计数,淋巴细胞亚群比例及淋巴细胞亚群计数。应用ROC曲线评价各指标对分泌性中耳炎复发的价值。结果:两组患者CD3^+,CD4^+,CD56^+,CD8^+,CD19^+比例比较差异有统计学意义(P<0.05)。两组淋巴细胞计数、白细胞计数比较差异无统计学意义(P>0.05);两组CD3^+,CD4^+,CD56^+,CD19^+淋巴细胞计数,C反应蛋白及降钙素原比较差异有统计学意义(P<0.05);两组CD8^+淋巴细胞计数比较差异无统计学意义(P>0.05)。CD8^+,CD19^+,PCT,CRP,CD3^+,CD4^+及CD56^+在预测分泌性中耳炎是否复发的AUC值分别为0.745,0.710,0.814,0.721,0.858,0.630,0.670。结论:复发组分泌性中耳炎患者免疫功能紊乱严重,可能是造成分泌性中耳炎复发的重要因素。在预测分泌性中耳炎是否复发的免疫指标中,CD3^+比例,降钙素原及CD8^+比例的敏感性及特异性较好。Objective:To observe the relationship between lymphocyte subsets,C-reactive protein and procalcitonin andrecurrence of secretory otitis media.Methods:118 cases of secretory otitis mediain hospital were retrospectively analyzed from January 2015 to December 2018.They were divided into primary group and recurrent group according to whether they had secretory otitis media before.White blood cell count,C-reactive protein,procalcitonin,lymphocyte count,lymphocyte subsets ratio and lymphocyte subsets count were compared between the two groups.The ROC curve was used to evaluate the various indexes for the recurrence of secretory otitis media.Results:The CD3^+,CD4^+,CD56^+,CD8^+and CD19^+in the primary group compared with the recurrence group were statistically significantdifferences(P<0.05).There was no statistically significant difference in lymphocyte count and white blood cell count between theprimary group and the recurrent group(P>0.05).The counts of CD3^+,CD4^+,CD56^+,CD19^+lymphocytes,C-reactive protein and procalcitonin in the primary group compared with the recurrence group were significantly significant differences(P<0.05).There was no significant difference in CD8^+lymphocyte count between the primary group and the recurrence group(P>0.05).The area under ROC curve of CD8^+,CD19^+,PCT,CRP,CD3^+,CD4^+,and CD56^+in predicting the recurrence of secretory otitis media were 0.745,0.710,0.814,0.721,0.858,0.630,0.670.Conclusion:The immune dysfunction of patients with secretory otitis media was more serious in the recurrent group,which may be an important factor for the recurrence of secretory otitis media.The sensitivity and specificity of CD3^+,PCT and CD8^+were better in predicting the recurrence of secretory otitis media.

关 键 词：淋巴细胞亚群 分泌性中耳炎 C反应蛋白 降钙素原 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]