不同免疫抗体水平下H9亚型AIV的排毒规律研究  

Study on the rules of viral shedding of H9 subtype AIV under different immune antibody titer

作　　者：盛媛 魏秀丽 徐恩民 刘娜 吴静[1] 艾武[1] 宋敏训[1] 王林 马秀丽[1] SHENG Yuan;WEI Xiuli;XU Enmin;LIU Na;WU Jing;AI Wu;SONG Minxun;WANG Lin;MA Xiuli(Shandong Institute of Poultry Science,Shandong Academy of Agricultural Science,The Key lab of poultry disease diagnosis and immunology of Shandong Province,Poultry Breeding Engineering Technology Center of Shandong Province,Jinan 250023,China;Institute of Veterinary Drug Quality Inspection of Shandong Province,Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products,Jinan 250100,China;Jinan Yimin Pharmaceutical Co.,Ltd,Jinan 250100,China)

机构地区：[1]山东省农业科学院家禽研究所,山东省禽病诊断与免疫重点实验室,山东省家禽育种工程技术研究中心,山东济南250023 [2]山东省兽药质量检验所,山东省畜产品质量安全监测与风险评估重点实验室,山东济南250100 [3]济南亿民动物药业有限公司,山东济南250105

出　　处：《家禽科学》2020年第12期5-7,共3页Poultry Science

基　　金：山东省农业重大应用技术创新项目(SD2019XM004);山东省重点研发计划项目(2019GNC106044);山东省现代农业产业技术体系项目(SDAIT-11-01);山东省农业科学院农业科技创新工程(CXGC2016A10);山东省农业科学院农业科技创新工程学科团队专项经费(编号CXGC2018E11)。

摘　　要：本研究旨在研究不同免疫抗体水平下H9亚型AIV的排毒规律。选取SPF鸡进行H9N2灭活疫苗免疫,根据HI效价将鸡群分成高、中、低三组,攻毒后分析其排毒差异。结果发现:抗体水平为9.44 log2时,个别鸡只仍会感染排毒,且抗体水平越低,感染排毒鸡只数量越多;当抗体水平达到11 log2时,鸡群不再排毒。To study the rules of viral shedding of H9 subtype AIV under different immune antibody titer.SPF chickens were immunized with H9N2 inactivated vaccine.According to HI titer,chickens were divided into three groups:high,medium and low.The results showed that when the antibody titer as 9.44 log2,some chickens were still infected with the virus.The lower the antibody titer was,the more chickens were infected.When the antibody titer of the chickens reached 11 log2,H9 subtype AIV were no longer shedding.

关 键 词：禽流感病毒 H9亚型 不同免疫抗体水平 排毒规律 

分 类 号：S858.312.4[农业科学—临床兽医学]