重度子痫前期患者血清CXCL10、CXCL16水平与肝肾功能损害的相关性研究  

Study on the Correlation between the Levels of Serum CXCL10 and CXCL16 and the Damage of Liver and Kidney Function in Patients with Severe Preeclampsia

作　　者：田华 庞颖 马娜 付晶[3] 詹敏 TIAN Hua;PANG Ying;MA Na;FU Jing;ZHAN Min(Department of Obstetrics,China Weapons Industry 521 Hospital,Xi'an,Shaanxi,710065,China;Department of Gynaecology,Northwest Women's and Children's Hospital,Xi'an,Shaanxi,710000,China;Department of Obstetrics and Gynecology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710061,China)

机构地区：[1]中国兵器工业五二一医院产科,陕西西安710065 [2]西北妇女儿童医院妇科,陕西西安710000 [3]西安交通大学第一附属医院妇产科,陕西西安710061

出　　处：《现代生物医学进展》2020年第22期4396-4400,共5页Progress in Modern Biomedicine

基　　金：陕西省卫生健康委科研项目(2018C0396)。

摘　　要：目的:探讨重度子痫前期患者血清趋化因子配体(CXCL)10、CXCL16水平与肝肾功能损害的相关性。方法:选取我院于2016年9月至2019年9月收治的轻度子痫前期患者65例(轻度组)、重度子痫前期患者80例(重度组),另选取同期60例正常妊娠孕妇为对照组,对比各组血清CXCL10、CXCL16、肝功能、肾功能相关指标水平,Pearson相关性分析重度组患者血清CXCL10、CXCL16水平与肝功能、肾功能相关指标间的关系。结果:重度组患者血清CXCL10、CXCL16、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、谷氨酰转肽酶(GGT)、尿酸(UA)、肌酐(Cr)、尿素氮(BUN)、胱抑素C(Cys-C)水平及24h尿蛋白均高于轻度组和对照组(P<0.05),直接胆红素(DBIL)、白蛋白(ALB)、碱性磷酸酶(ALP)、肌酐清除率(CCr)均低于轻度组和对照组(P<0.05);轻度组血清CXCL10、CXCL16、ALT、AST、UA、Cr水平及24 h尿蛋白高于对照组(P<0.05),ALP和CCr低于对照组(P<0.05),轻度组和对照组的ALB、DBIL、GGT、BUN、Cys-C水平比较无差异(P>0.05)。Pearson相关性分析结果显示,重度子痫前期患者CXCL10、CXCL16与ALT、AST、UA、Cr、24h尿蛋白呈正相关(P<0.05),与ALP呈负相关(P<0.05)。结论:血清CXCL10、CXCL16水平升高与重度子痫前期患者肝肾功能改变有关,临床可能通过检测二者水平来辅助评估重度子痫前期患者的病情以便及时予以治疗。Objective:To explore the correlation between the levels of serum CXC chemokine ligand(CXCL)10 and CXCL16 and the damage of liver and kidney function in patients with severe preeclampsia.Methods:65 patients with mild preeclampsia(mild group)and 80 patients with severe preeclampsia(severe group)admitted to our hospital from September 2016 to September 2019 were selected as research object,and 60 pregnant women with normal pregnancy in the same period were selected as the control group.The level of serum CXCL10,CXCL16,liver function and kidney function were compared in each group.Pearson correlation analysis was used to analyze the relationship between the level of serum CXCL10,CXCL16 and liver function and kidney function in severe group.Results:The levels of CXCL10,CXCL16,alanine aminotransferase(AST),aspartate aminotransferase(AST),glutamyltranspeptidase(GGT),uric acid(UA),creatinine(Cr),urea nitrogen(BUN),cystatin C(Cys-C)and 24 h urinary protein in severe group were higher than those in mild group and control group(P<0.05),direct bilirubin(DBIL),albumin(ALB),alkaline phosphatase(ALP),creatinine clearance rate(CCr)were lower than those in mild group and control group(P<0.05).The levels of serum CXCL10,CXCL16,ALT,AST,UA,Cr and 24 h urinary protein in the mild group were higher than those in the control group(P<0.05),ALP and CCr were lower than those in the control group(P<0.05).There were no differences in ALB,DBIL,GGT,BUN,Cys-C between mild group and control group(P>0.05).Pearson correlation analysis showed that CXCL10 and CXCL16 were positively correlated with ALT,AST,UA,Cr,24 h urinary protein(P<0.05),and negatively correlated with ALP(P<0.05).Conclusion:The levels of serum CXCL10 and CXCL16 in patients with preeclampsia are related to the changes of liver and kidney function,Clinical examination of the levels two indexes may help to evaluate the condition of patients with severe preeclampsia for timely treatment.

关 键 词：子痫前期 重度 趋化因子配体10 趋化因子配体16 肝功能 肾功能 

分 类 号：R714.245[医药卫生—妇产科学]