耐药基因数据库概述  

Overview of antibiotic resistance genes database

作　　者：杨兵 梁晶[2] 刘林梦 李雪佩 王荃[3] 任一 Bing Yang;Jing Liang;Linmeng Liu;Xuepei Li;Quan Wang;Yi Ren(Shanghai Majorbio Biomedical Technology Co.Ltd.,Shanghai 201318,China;Department of Critical Care Medicine,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080,China;Department of Immunology,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]上海美吉生物医药科技有限公司,上海201318 [2]上海交通大学附属第一人民医院急诊危重病科,上海200080 [3]天津医科大学免疫学系,天津300070

出　　处：《生物工程学报》2020年第12期2582-2597,共16页Chinese Journal of Biotechnology

基　　金：天津市教委科研计划重点项目(No.2017ZD12)资助。

摘　　要：抗生素是人类历史上的革命性发现,其临床应用挽救了无数患者的生命。但是随着抗生素的广泛使用和滥用,越来越多的病原菌产生了耐药性,甚至出现了具有多重耐药性的“超级细菌”。在人类与病原菌斗争的军备竞赛中,人类即将面临无药可用的境地。针对微生物的耐药性、耐药机制及耐药性传播的研究吸引了众多科研工作者的目光,各种耐药基因数据库以及耐药基因分析工具应运而生。文中对目前耐药领域的基因数据库进行收集整理,从数据库类型、数据特征、耐药基因预测模型以及可分析序列的类型等方面对这些数据库进行论述和介绍。此外,文中对抗金属离子和抗杀菌剂的基因数据库也有所涉及,将为如何选择及使用耐药基因数据库提供参考和帮助。The discovery of antibiotics is a big revolution in human history,and its clinical application has saved countless lives.However,with the widespread and abuse of antibiotics,many pathogens have developed resistance,and even“Super Bacteria”resistance to multiple drugs have evolved.In the arms race between humans and pathogens,humans are about to face a situation where no medicine is available.Research on microbial antibiotic resistance genes,resistance mechanisms,and the spread of resistance has attracted the attention of many scientific researchers,and various antibiotic resistance gene databases and analysis tools have emerged.In this review,we collect the current databases that focus on antibiotics resistance genes,and discuss these databases in terms of database types,data characteristics,antibiotics resistance gene prediction models and the types of analyzable sequences.In addition,a few gene databases of anti-metal ions and anti-biocides are also involved.It is believed that this summary will provide a reference for how to select and use antibiotic resistance gene databases.

关 键 词：抗生素 耐药基因 超级细菌 可移动元件 

分 类 号：R378[医药卫生—病原生物学]