禽流感纳米颗粒疫苗的研究进展  

Research progress of avian influenza nanoparticle vaccine

作　　者：潘亮奇 李硕 吴梅花 于亚南 林嘉特 孙华鹏 崔新鑫 许丰祥 刘杨 李明亮 焦培荣 廖明 孙海亮 PAN Liang-qi;LI Shuo;WU Mei-hua;YU Ya-nan;LIN Jia-te;SUN Hua-peng;CUI Xin-xin;XU Feng-xiang;LIU Yang;LI Ming-liang;JIAO Pei-rong;LIAO Ming;SUN Hai-liang(College of Veterinary Medicine,South China Agricultural University/National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control/Key Laboratory of Zoonoses,Ministry of Agriculture/Key Laboratory for Prevention and Control of Zoonotic Diseases of Guangdong Province,Guangzhou 510642,China)

机构地区：[1]华南农业大学兽医学院,人兽共患病防控制剂国家地方联合工程实验室,农业农村部人畜共患病重点实验室,广东省动物源性人兽共患病预防与控制重点实验室,广东广州510642

出　　处：《中国兽医科学》2020年第12期1572-1579,共8页Chinese Veterinary Science

基　　金：国家自然科学基金项目(31830097);广东省自然科学基金面上项目(2018A0303130092)。

摘　　要：禽流感在世界范围内不断暴发,不但给养禽业造成了巨大的经济损失,而且给公共卫生安全造成了一定威胁。当前,疫苗免疫仍然是预防与控制禽流感的主要手段。而纳米疫苗具有免疫剂量小、效应时间长、定点靶向性、生物相容性好等特点,因此寻求和开发新型纳米疫苗用于防控禽流感具有很强的现实意义。本文从纳米疫苗的种类、疫苗抗原的类型、免疫接种途径以及应用前景方面,对禽流感纳米颗粒疫苗的研究进展进行论述,以期为新型禽流感纳米疫苗的研发提供参考。Avian influenza continues to outbreak around the world,not only cause huge economic losses to the poultry industry,but also pose certain threat to public health.Currently,immunization is still the main way for prevention and control of avian influenza.Nanoparticle vaccines show many good features,such as small immunization dose,long effect time,targeting,and good biocompatibility.Therefore,it is significant to seek and develop novel nanoparticle vaccines for prevention and control of avian influenza.Development of avian influenza nanoparticle vaccines is discussed in this review including nanoparticle vaccine types,vaccine antigen types,immunization methods and application prospects.It is expected to provide new ideas for the further development of novel avian influenza nanoparticle vaccines.

关 键 词：禽流感 纳米疫苗的种类 疫苗抗原的类型 免疫接种途径 

分 类 号：S852.659.5[农业科学—基础兽医学]