组织工程化神经导管修复外周性面神经缺损的研究进展  

Research Progress of Tissue-Engineered Nerve Conduits in Repair of Peripheral Facial Nerve Defect

作　　者：徐万林 杨雯君[1] XU Wanlin;YANG Wenjun(Department of Oromaxillqfacial Head and Neck Oncology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室&上海市口腔医学研究所,上海市200011

出　　处：《组织工程与重建外科杂志》2020年第6期509-513,共5页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：上海交通大学医学院附属第九人民医院基础研究助推计划(JYZZ086B)。

摘　　要：外周性面神经缺损仍是临床常见及较难解决的问题,而组织工程化神经导管为修复面神经缺损带来了新的希望。与传统的自体/异体神经移植相比,组织工程化神经导管具备来源广泛、良好的生物相容性、避免二次创伤和减少免疫排斥等优点。组织工程化神经导管可由不同种类的种子细胞、多种生长因子及各式支架材料组合形成。大量体内外实验证实,组织工程化神经导管能够有效促进外周性面神经再生。本文对基于组织工程原理构建的用于修复外周性面神经缺损的神经导管的国内外相关研究报道进行综述,为组织工程化神经导管修复面神经缺损提供理论依据。The peripheral facial nerve defect is still a common and difficult problem in clinic and tissue-engineered nerve conduits bring new way in repair of facial nerve defect.With contrast to traditional autogenous/allogeneic nerve transplantation,the tissue-engineered nerve conduits have several obvious advantages,such as wide sources,good biocompatibility,avoiding secondary trauma and reducing immune rejection.The tissue-engineered nerve conduits may be composed of various combinations by seed cells,growth factors and scaffolds,which could effectively improve the regrowth of peripheral facial nerve defect through massive in vitro and in vivo experiments.In this paper,the research progress of nerve conduits based on the tissue engineering techniques in repair of peripheral facial nerve defect was reviewed,providing theoretical basis for the repair of facial nerve defect with tissue-engineered nerve conduits.

关 键 词：面神经 外周性神经 神经再生 神经导管 组织工程 

分 类 号：R651.3[医药卫生—外科学]