一起新型冠状病毒肺炎家庭聚集性疫情流行病学和临床特征调查分析  

Analysis of the epidemiological and clinical characteristics of a 2019 corona virus disease family cluster

作　　者：温志红[1] 唐慧荷 王浜琴[2] 刘兴夏 陆春久 张迪雯 代艳[1] WEN Zhi-hong;TANG Hui-he;WANG Bang-qin(Department of Pediatrics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China)

机构地区：[1]广西壮族自治区人民医院儿科,南宁530021 [2]广西壮族自治区人民医院风湿免疫科,南宁530021

出　　处：《中国临床新医学》2020年第12期1250-1254,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的分析一起新型冠状病毒肺炎(COVID-19)家庭聚集性疫情的流行病学及临床特征,为进一步做好防控工作提供依据。方法(1)流行病学调查:通过向患者本人、家属以及其他知情人员(医务人员)进行电话、面对面访谈,收集所有患者暴露史、家庭聚集性发病情况、医学/家庭隔离情况。(2)临床资料收集:通过查阅病历、向患者本人及家属询问病史,收集患者一般情况、临床症状、体征、实验室检查、影像学结果、治疗方案、疾病转归及近期预后。结果(1)1个家庭共11例COVID-19确诊患者,具有与武汉疫区确诊COVID-19指示病例直接或间接密切接触、共同生活流行病学特征。(2)11例COVID-19确诊患者均无重症患者,儿童临床表现轻且不典型。(3)经治疗达出院标准COVID-19患者出院后有4例新型冠状病毒(SARS-CoV-2)核酸复阳,1例成人症状轻微,3例儿童均无症状。结论(1)聚集性发病是该次疫情的重要流行特征,家庭内密切接触是儿童COVID-19感染主要方式。(2)出院后SARS-CoV-2核酸复阳性并不能用于评估疾病严重程度。Objective To investigate the epidemiological and clinical characteristics of a 2019 corona virus disease(COVID-19)family cluster,so as to provide evidence for further prevention and control efforts.Methods(1)Epidemiological investigation:all the information of exposure histories,family clusters,and medical/home isolation was collected through telephone and face-to-face interviews with the patients,family members,and other informed persons(medical personnel).(2)Clinical data collection:the patients′general condition,clinical symptoms,signs,laboratory examinations,imaging results,treatment planes,disease outcomes and short-term prognoses were collected by consulting the medical records and inquiring the medical history of the patients and their family members.Results(1)There were 11 confirmed COVID-19 cases in the family,with the epidemiological characteristics of living together in close direct or indirect contact with the COVID-19 index cases confirmed in the epidemic area of Wuhan.(2)None of the 11 confirmed cases of COVID-19 had severe symptoms,and the clinical manifestations of the children were mild and atypical.(3)After treatment,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid was retested to be positive in 4 COVID-19 patients who were discharged from the hospital because of meeting discharge criteria,of whom,1 adult had mild symptoms and 3 children had no symptoms.Conclusion(1)Clustering is an important epidemic feature of this outbreak,and close family contact is the main form of COVID-19 infection in children.(2)The positive results of SARS-CoV-2 nucleic acid retest after discharge can not be used to assess the severity of the disease.

关 键 词：新型冠状病毒肺炎 家庭聚集 流行病学 临床特征 

分 类 号：R563.1[医药卫生—呼吸系统]