新型氨基糖苷类药物plazomicin的临床应用研究进展  

Research progress in the clinical application of a novel aminoglycoside plazomicin

作　　者：王亚乐 谢小倩 赵则月 罗沙沙(综述) 李晓天(审校)[2] WANG Ya-le;XIE Xiao-qian;ZHAO Ze-yue(Department of Pharmacy, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, China)

机构地区：[1]河南科技大学第一附属医院药学部,洛阳471000 [2]郑州大学药学院,河南450001

出　　处：《中国临床新医学》2020年第12期1273-1277,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：河南省科技厅攻关项目(编号:162102310540)。

摘　　要：plazomicin是一种由西索米星为起始原料,经化学合成而得的新型氨基糖苷类药物,对大多数多药耐药菌具有较高的活性。与其他氨基糖苷类药物相似,plazomicin通过与细菌核糖体30S亚基结合抑制细菌蛋白质的合成。对大多数氨基糖苷类修饰酶有效,但不能抑制16S rRNA甲基化酶。该文对plazomicin的化学结构、抗菌机制、耐药机制、体内外抗菌活性、药动学、药效学、临床应用以及药物配伍方面作一综述。Plazomicin is a novel aminoglycoside that is chemically synthesized from sisomicin with enhanced activity against most multidrug-resistant pathogens.Similar to other aminoglycosides,plazomicin inhibits protein synthesis by binding to the bacterial 30S ribosomal subunit.Plazomicin is engineered to overcome the most common aminoglycoside-modifying enzymes,but is not active against 16S rRNA methyltransferase.In this paper,we review the chemical structure,antibacterial mechanism,mechanism of drug resistance,antibacterial activity in vitro and in vivo,pharmacokinetics,pharmacodynamics,clinical application and drug compatibility of plazomicin.

关 键 词：Plazomicin 抗菌活性 临床应用 复杂性尿路感染 

分 类 号：R978.1[医药卫生—药品]