机构地区:[1]河南中医药大学第三附属医院,河南郑州450000
出 处:《世界中西医结合杂志》2020年第11期2125-2129,共5页World Journal of Integrated Traditional and Western Medicine
基 金:河南省高等学校重点科研项目(17A360011);河南省中医药科学研究专项课题(2019ZY2152)。
摘 要:目的研究清气化痰汤加减治疗对慢性阻塞性肺疾病急性加重期(Acute exacerbation chronic obstructive pulmonary disease,AECOPD)痰热壅肺证患者血清单核细胞趋化蛋白1(MCP-1)、可溶性髓样细胞触发受体-1(s TREM-1)水平的影响。方法选取2018年6月—2019年12月期间在河南中医药大学第三附属医院肺病科收治的AECOPD患者120例,按照随机数字表法分为两组,每组各60例。对照组使用西医基础治疗,治疗组在对照组基础上予清气化痰汤加减治疗,治疗周期均为2周。比较两组临床疗效、治疗前后血气分析指标、肺功能指标及血清MCP-1、s TREM-1水平变化。结果治疗后治疗组临床总有效率为93.33%(56/60),对照组临床总有效率为78.33%(47/60),两组比较差异有统计学意义(P<0.05)。两组患者治疗后Pa O2均升高,Pa CO2均降低与治疗前比较,差异有统计学意义(P<0.05),且治疗组治疗后Pa O2升高指数高于对照组,Pa CO2降低指数低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后两组患者FEV1、FEV1/FVC指数均升高与治疗前比较,差异有统计学意义(P<0.05),且治疗组FEV1、FEV1/FVC指数升高优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后两组患者血清MCP-1、s TREM-1水平均降低与治疗前比较,差异有统计学意义(P<0.05),且治疗组血清MCP-1、s TREM-1降低水平优于对照组,两组比较差异有统计学意义(P<0.05)。结论清气化痰汤加减治疗可有效缓解慢性阻塞性肺疾病急性加重期患者的临床症状,改善肺功能,降低炎症反应,值得临床进一步推广应用。Objective To study the effect of Qingqi Huatan Decoction on serum monocyte chemoattractant protein1(MCP-1)Soluble triggering receptor expressed on myeloidcells1(s TREM-1)level in patients with chronic obstructive pulmonary disease in acute exacerbation of chronic obstructive pulmonary disease.Methods A selection of 120 AECOPD patients admitted to the Pulmonary Department of the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from June 2018 to December 2019 were divided into two groups according to a random number table,with 60 cases in each group.The control group was treated with western medicine,and the treatment group was treated with Qingqi Huatan Decoction on the basis of the control group.The treatment period was 2 weeks.The clinical effects of the two groups were compared,blood gas analysis indexes,lung function indexes and serum MCP-1 and s TREM-1 levels were compared before and after treatment.Results After treatment,the total clinical effective rate of the treatment group was 93.33%(56/60),and the total clinical effective rate of the control group was 78.33%(47/60).The difference between the two groups was statistically significant(P<0.05).Pa O2 increased and Pa CO2 decreased in both groups after treatment.Compared with before treatment,the difference was statistically significant(P<0.05).After treatment,Pa O2 increased index was higher than control group,and Pa CO2 decreased index was lower than control group.,The difference between the two groups was statistically significant(P<0.05).After treatment,the FEV1,FEV1/FVC index of the two groups of patients increased compared with before treatment,the difference was statistically significant(P<0.05),and the increase of FEV1,FEV1/FVC index of the treatment group was better than that of the control group,there was a difference between the two groups There is statistical significance(P<0.05).After treatment,the serum MCP-1 and s TREM-1 levels of the two groups of patients decreased compared with those before treatment,the differe
关 键 词:清气化痰汤加减 慢性阻塞性肺疾病急性加重期 MCP-1 STREM-1
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