尼可地尔治疗老年2型糖尿病合并不稳定型心绞痛患者效果观察  

Effect of nicorandil in elderly patients with type 2 diabetes and unstable angina

作　　者：高香[1] 刘方圆 韩晓真 沈丁丁[1] 王锡岭[1] 吕玲 李志玲[1] GAO Xiang;LIU Fangyuan;HAN Xiaozhen;SHEN Dingding;WANG Xiling;LV Ling;LI Zhiling(Department of Geriatrics of Weifang People's Hospital Affiliated to Weifang Medical University,Weifang 261041,China;Department of Rheumatology of Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China)

机构地区：[1]潍坊医学院附属潍坊市人民医院保健一科,山东潍坊261041 [2]复旦大学附属华山医院风湿科,上海200040

出　　处：《老年医学研究》2020年第2期3-6,共4页Geriatrics Research

基　　金：山东省潍坊市卫计委资助项目(wfwsjs_2018_009,尼可地尔在老年2型糖尿病合并不稳定性心绞痛患者中的疗效分析)。

摘　　要：目的探讨尼可地尔对老年2型糖尿病合并不稳定型心绞痛患者的疗效。方法选择2型糖尿病合并不稳定型心绞痛患者172例,按照随机数字表法分为对照组和尼可地尔组各86例。对照组在给予控制血糖及冠心病标准二级预防治疗基础上,口服单硝酸异山梨酯片20 mg 2次/d;尼可地尔组在给予控制血糖及冠心病标准二级预防治疗基础上,口服尼可地尔片5 mg 3次/d。两组均连续治疗8周。记录两组患者心绞痛改善情况、心电图改善情况及治疗前后血糖、血脂、肝肾功能、心功能、心肌酶等血清学指标,记录两组患者不良反应发生率。结果尼可地尔组心绞痛改善、心电图改善的总有效率均高于对照组(P分别为0.004、0.001)。两组治疗前后血清学指标差异均无统计学意义(P均>0.05)。尼可地尔组头痛发生率低于对照组(P=0.01)。结论尼可地尔可有效减轻老年2型糖尿病合并不稳定型心绞痛患者的心绞痛发作、改善心电图表现,头痛发生率低,可安全使用。Objective To study the effect of nicorandil in elderly patients with type 2 diabetes and unstable angina.Methods A total of 172 elderly patients with type 2 diabetes and unstable angina were selected and divided into a control group(86 cases)and a nicorandil group(86 cases)according to random number table.The control group was given oral 20 mg 2 times/day of isosorbide mononitrate tablets on the basis of standard secondary prevention for coronary heart disease and treatment plan for blood glucose control.In the nicorandil group,oral administration of nicorandil tablets 5 mg 3 times/day was given on the basis of the standard secondary prevention for coronary heart disease and treatment plan for blood glucose control.Both groups were treated continuously for 8 weeks.We record the improvement of angina pectoris,improvement of ECG,blood glucose,blood lipid,liver and kidney function,cardiac function,myocardial enzymes and other serological indicators before and after treatment,and the adverse reactions of patients in the two groups.Results The total effective rate of angina pectoris and ECG improvement in the nicorandil group was significantly higher than that in the control group(P=0.004,P=0.001).There was no statistically difference on blood glucose between nicorandil group and control group(P>0.05).The incidence of headache in nicorandil group was lower than that in control group(P=0.01).Conclusion Nicorandil can effectively improve the angina pectoris and ECG of elderly patients with type 2 diabetes and unstable angina,had a lower incidence of headache,and it can be used safely.

关 键 词：尼可地尔 单硝酸异山梨酯 2型糖尿病 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]