联合检测血清GC、SERPINA1和EDN1在子宫肌瘤中的诊断价值  

The diagnostic value of combined detection of serum GC,SERPINA1 and EDN1 in uterine fibroids

作　　者：李艳[1] 闫丽明[1] 杨敏[1] 王媛[1] 贺晶[1] LI Yan;YAN Li-ming;YANG Min;WANG Yuan;HE Jing(Department of Gynecology Second Disease Area,the Affiliated Hospital of Yan an University,Yan an 716000,Shaanxi,China)

机构地区：[1]延安大学附属医院妇科二病区,陕西延安716000

出　　处：《川北医学院学报》2020年第6期1043-1046,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨联合检测血清GC维生素D结合蛋白(GC)、Serpin家庭成员1(SERPINA1)和内皮素1(EDN1)在子宫肌瘤中的诊断价值。方法:66例子宫肌瘤患者为子宫肌瘤组、59例子宫腺肌病患者为子宫肌病组、67例健康体检者为对照组。酶联吸附试验(ELISA)检测3组血清中GC、SERPINA1和EDN1表达量。用受试者工作特征曲线(ROC)AUC分析GC、SERPINA1和EDN1在子宫肌瘤中的诊断价值。结果:子宫肌瘤组血清GC、SERPINA1和EDN1表达量均高于子宫腺肌病组和对照组(P<0.05),子宫腺肌病组血清GC、SERPINA1和EDN1表达量均高于对照组(P<0.05)。子宫肌瘤组与子宫腺肌病组GC、SERPINA1和EDN1灵敏度分别为90%、92%和92%,特异度分别为92%、91%和91%。子宫肌瘤组与对照组GC、SERPINA1、EDN1的灵敏度分别为95%、95%和98%,特异度分别为94%、93%和94%。血清中GC、SERPINA1和EDN1联合对子宫肌瘤的诊断的的灵敏度为89.39%,特异度为96.61%,准确度为92.80%。结论:联合检测血清GC、SERPINA1和EDN1可作为子宫肌瘤诊断的潜在标志物。Objective:To prospectively explore the diagnostic value of combined detection of serum GC,SERPINA1 and EDN1 in uterine fibroids.Methods:66 patients with early uterine fibroids were in the uterine fibroid group,59 patients with adenomyosis were in the adenomyosis group,and 67 healthy patients were in the healthy control group.The expression levels of GC,SERPINA1 and EDN1 in serum were detected by ELISA.The diagnostic significance of GC,SERPINA1 and EDN1 in uterine fibroids was analyzed by AUC of receiver operating characteristic curve(ROC).Results:The expressions of GC,SERPINA1 and EDN1 in serum of the uterine fibroid group were higher than those of the adenomyosis group and healthy control group(P<0.05).The expressions of GC,SERPINA1 and EDN1 in serum of the adenomyosis group were all higher than those of the healthy control group(P<0.05).The sensitivity of GC,SERPINA1 and EDN1 in the myoma group and the adenomyosis group were 90%,92%,92%,and the specificity was 92%,91%,91%,respectively.The sensitivity of GC,SERPINA1 and EDN1 combined in serum for the diagnosis of uterine fibroids was 89.39%,the specificity was 96.61%,and the accuracy was 92.80%.Conclusion:Combined detection of GC,SERPINA1 and EDN1 in serum may be a potential marker for diagnosis of uterine fibroids.

关 键 词：GC维生素D结合蛋白 Serpin家庭成员1 内皮素1 子宫肌瘤 诊断 

分 类 号：R711[医药卫生—妇产科学]