呼出气一氧化氮与亚急性咳嗽及慢性咳嗽的相关性研究  

Study on the correlation between exhaled nitric oxide and subacute cough and chronic cough

作　　者：王雪利 林照[2] WANG Xue-li;LIN Zhao(Department of Respiratory Medicine,Yifu Hospital Affiliated to Nanjing Medical University;Department of Critical Medicine,Nanjing Jiangning Hospital,Nanjing 210000,Jiangsu,China)

机构地区：[1]南京医科大学附属逸夫医院呼吸内科 [2]南京市江宁医院重症医学科,江苏南京210000

出　　处：《川北医学院学报》2020年第6期1051-1054,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨呼出气一氧化氮(FeNO)与亚急性咳嗽及慢性咳嗽的相关性,并观察其在治疗指导中的应用价值。方法:将266例主诉为咳嗽的患者分为亚急性咳嗽组(n=155)和慢性咳嗽组(n=111),收集并对比两组患者的病情状况、治疗前后的FeNO水平变化及其对治疗的反应性。结果:亚急性咳嗽组中,56例患者为变异性哮喘(CVA),33例患者为嗜酸粒细胞性支气管炎(EB),66例患者为其他原因所致咳嗽。慢性咳嗽组中,41例患者为CVA,24例患者为EB,46例患者为其他原因所致咳嗽。治疗前,慢性咳嗽组患者FeNO水平为(28.13±4.67)ppb,高于亚急性咳嗽组的(21.43±5.12)ppb,差异有统计学意义(P<0.05)。亚急性咳嗽组中,CVA患者FeNO水平为(32.94±5.10)ppb,高于EB患者的(27.31±3.87)ppb和其他病因患者的(21.35±4.06)ppb,差异均具有统计学意义(P<0.05)。但慢性咳嗽组中,CVA患者的FeNO水平与EB患者和其他病因患者比较,差异无统计学意义(P>0.05)。对各组患者治疗前后FeNO及咳嗽评分进行相关性分析,结果显示:FeNO与患者咳嗽评分间呈正相关(r=0.3284,P<0.001);单独分析亚急性咳嗽组,FeNO与患者咳嗽评分间呈正相关(r=0.3162,P<0.001);单独分析慢性咳嗽组,FeNO与患者咳嗽评分间同样呈正相关(r=0.3752,P<0.001)。结论:亚急性咳嗽或慢性咳嗽患者的FeNO水平与病情严重程度呈正相关关系;通过对患者进行FeNO检测,可对患者的病因及治疗效果进行一定的判断和评估。Objective:To investigate the expression of fractional exhaled nitric oxide(FeNO)in patients with subacute cough and chronic cough,and to observe its application value in treatment guidance.Methods:266 patients were divided into subacute cough group(155 cases)and chronic cough group(111 cases)according to their condition.The state of illness,the changes of FeNO levels before and after treatment and the response to treatment were collected and compared between the two groups.Results:Among the subacute cough patients,56 patients had variant asthma(CVA),33 patients had eosinophilic bronchitis(EB),and 66 patients had cough due to other causes.In the chronic cough group,41 patients were CVA,24 patients were EB,and 46 patients were cough caused by other reasons.Before treatment,the FeNO level of patients with chronic cough was(28.13±4.67)ppb,which was significantly higher than that of patients with subacute cough(21.43±5.12)ppb,the difference was statistically significant(P<0.05).In the subacute cough group,the FeNO level of CVA patients was(32.94±5.10)ppb,which was significantly higher than that of EB patients(27.31±3.87)ppb and other etiological patients(21.35±4.06)ppb,the difference was statistically significant(P<0.05).However,there was no significant difference in FeNO levels between CVA patients and EB patients and other etiological patients in the chronic cough group(P>0.05).Correlation analysis of FeNO and cough scores between patients before and after treatment in each group showed that there was a significant positive correlation between FeNO and cough scores(r=0.3284,P<0.001),in a separate analysis of the subacute cough group,there was a significant positive correlation between FeNO and the patient's cough score(r=0.3162,P<0.001),in a separate analysis of the chronic cough group,FeNO was also positively correlated with the patient's cough score(r=0.3752,P<0.001).Conclusion:The FeNO level of patients with subacute cough or chronic cough is positively correlated with the severity of the disease,by testing

关 键 词：呼出气一氧化氮 亚急性咳嗽 慢性咳嗽 变异性哮喘 嗜酸粒细胞性支气管炎 

分 类 号：R562.2[医药卫生—呼吸系统]