南充市新型冠状病毒肺炎临床特征及病情影响因素分析  

Novel Coronavirus Pneumonia in Nanchong:clinical characteristics and risk factors

作　　者：张廷君[1] 向琴 熊建 范晖 刘凤君[1] ZHANG Ting-jun;XIANG Qin;Xiong Jian;FAN Hui;LIU Feng-jun(Department of Infection,Affiliated Hospital of North Sichuan Medical College,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Infection,Nanchong Central Hospital,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Neurology,Nanchong Central Hospital,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Preventive Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院感染科,四川南充637000 [2]南充市中心医院感染科,四川南充637000 [3]南充市中心医院神经内科,四川南充637000 [4]川北医学院预防医学系,四川南充637000

出　　处：《川北医学院学报》2020年第6期1123-1126,共4页Journal of North Sichuan Medical College

基　　金：四川省南充市市校合作项目(19SXHZ0055);川北医学院校级课题(CBY16-A-YB27)。

摘　　要：目的:了解南充地区新型冠状病毒感染者的临床特征及预后,分析影响患者严重程度的因素。方法:收集2020年1月20日至2020年3月15川北医学院附属医院及南充市中心医院新型冠状病毒肺炎住院的30例患者的临床资料,包括其血液化验、T淋巴细胞亚群检测、治疗及预后情况等情况。将所有患者分为普通型、重型和危重型组,并对所有病人的临床特征进行回顾性分析、描述性分析、Spearman相关性分析和Logistic回归分析,以确定其病情影响因素。结果:患者的主要临床表现为发热、咳嗽、气促、咽痛,少数则表现为头痛,腹泻和头晕。肺部影像学双侧病灶的占多数(70%),单侧病灶仅有少量(30%)。咳嗽、气促、发病至入院时间、入院前最高体温、降钙素原、氧分压、氧合指数、CD3+、CD4+、CD8+T淋巴细胞的水平与病情严重程度显著相关(P<0.05)。且氧分压、氧合指数通过了Logistic回归分析的Wald检验。结论:南充地区新型冠状病毒肺炎的主要表现为发热、咳嗽、气促、咽痛等,氧分压及氧合指数是新型冠状病毒肺炎病情的严重程度的主要影响因素。Objective:To research the clinical characteristics of novel coronavirus infection in Nanchong area(Sichaun,China)and the factors affecting their severity.Methods:The clinical cases of inpatients with 2019 novel coronavirus(2019-nCoV)were collected in Affiliated Hospital of North Sichuan Medical College and Nanchong Center Hospital from January 20,2020 to March 5,2020,including their blood specimens,T lymphocyte subsets,the responses to treatment and prognosis.All patients were divided into normal,severe and critical groups,and the retrospective,descriptive,Spearman correlation and Logistic regression analysis of the clinical characteristics of all patients was carried out to determine the factors affecting their condition.Results:The main clinical manifestations of the patients were fever,cough,shortness of breath and sore throat,while a few manifested as headache,diarrhea and dizziness.In lung imaging,bilateral lesions accounted for the majority(70%),and unilateral lesions were only a few(30%).Furthermore,ten indicators including cough,shortness of breath,period from onset to hospitalization,maximum temperature before hospitalization,procalcitonin,partial pressure of oxygen,oxygenation index,the context of CD3+,CD4+and CD8+T lymphocytes were significantly related to the severity of 2019-nCoV(P<0.05).Moreover,the partial pressure of oxygen and oxygenation index accorded with the Wald test of logistic regression analysis.Conclusion:The 2019-nCoV in Nanchong is characterized by fever,cough,shortness of breath,sore throat and so on.Particularly,the partial pressure of oxygen and oxygenation index is the principal factor affecting the severity of 2019-nCoV.

关 键 词：新型冠状病毒肺炎 COVID-19 SARS-CoV-2 影响因素 

分 类 号：R512.99[医药卫生—内科学]