盐酸多巴胺注射液联合心脉隆注射液对老年扩张型心肌病中晚期患者心脏功能及心肌细胞炎性反应的影响  

The effect of dopamine hydrochloride injection combined with Xinmailong injection on cardiac function and myocardial cell inflammatory response in elderly patients with advanced dilated cardiomyopathy

作　　者：贾海燕 李建辉 张艺 Jia Haiyan;Li Jianhui;Zhang Yi(Department of Cardiology,Xixia County People′s Hospital,Henan 474500,China)

机构地区：[1]河南省西峡县人民医院心内科,474500

出　　处：《山西医药杂志》2020年第24期3388-3391,共4页Shanxi Medical Journal

摘　　要：目的探究盐酸多巴胺注射液联合心脉隆注射液对老年扩张型心肌病中晚期患者心脏功能及心肌细胞炎性反应的影响。方法选取我科2017年8月至2019年8月129例老年扩张型心肌病中晚期患者作为研究对象,根据随机数字表法分为对照组64例和观察组65例。2组患者均接受常规抗心力衰竭治疗,对照组给予心脉隆注射液治疗,观察组在对照组基础上增加盐酸多巴胺注射液治疗,10 d后,对比2组患者临床疗效、心脏功能:入院24 h及出院时左心室舒张末内径(LVEDd)、左心室射血分数(LVEF)、6 min步行距离(6 MWD)、心脏指数(CI)、心排血量(CO);心肌细胞炎性反应:血清N-末端脑钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)水平;药物安全性。结果观察组总有效率97%高于对照组73%,LVEF、CI、CO、6MWD高于对照组,NT-proBNP、hs-CRP、LVEDd低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为9%,对照组为8%,差异无统计学意义(P>0.05)。结论盐酸多巴胺注射液联合心脉隆注射液治疗老年扩张型心肌病中晚期患者,可提升心脏功能,降低炎性反应,提高临床疗效,药物安全性较高。Objective To explore the effects of dopamine hydrochloride injection combined with Xinmailong injection on cardiac function and myocardial inflammatory response in elderly patients with dilated cardiomyopathy in the middle and late stages.Methods A total of 129 elderly patients with dilated cardiomyopathy in the middle and late stages of our department from August 2017 to August 2019 were selected as the research subbjects.According to the random number table method,they were divided into a control group and an observation group.Both groups of patients received conventional anti-heart failure treatment,64 patients in the control group were treated with Xinmailong injection,and 65 patients in the observation group were treated with dopamine hydrochloride injection on the basis of the control group.After 10 days,the clinical efficacy and cardiac effects of the two groups were compared,including 24 hours after admission and discharge,left ventricular end-diastolic diameter(LVEDd),left ventricular ejection fraction(LVEF),6-min walking distance(6 MWD),cardiac index(CI),cardiac output(CO);myocardial cell inflammatory reaction:serum N-terminal pro-brain natriuretic peptide(NT-proBNP),high-sensitivity C-reactive protein(hs-CRP)levels;drug safety.Results The total effective rate of the observation group was 97%higher than that of the control group 73%.LVEF,CI,CO and 6MWD were higher than those of the control group;NT-proBNP,hs-CRP and LVEDd were lower than those of the control group,there was a significant difference(P<0.05)The incidence of adverse reactions in the observation group was 9%,higher than that in the control group 8%,with no significant difference(P>0.05).Conclusion Dopamine hydrochloride injection combined with Xinmailong injection for the treatment of elderly patients with dilated cardiomyopathy can improve cardiac function,reduce inflammatory response,improve clinical efficacy,and have high drug safety.

关 键 词：多巴胺药 心脉隆注射液 心肌病 扩张型 心脏功能试验 心肌细胞炎性反应 

分 类 号：R542.2[医药卫生—心血管疾病]