复合辅酶注射液治疗慢性乙型病毒性肝炎的效果  

Effect of compound coenzyme injection on chronic viral hepatitis B

作　　者：王楠 谢友东 宋宝君 WANG Nan;XIE Youdong;SONG Baojun(First Treatment Area,Fushun Infectious Diseases Hospital of Liaoning,Fushun,Liaoning,113015,China;Six Treatment Areas,Fushun Infectious Diseases Hospital of Liaoning,Fushun,Liaoning,113015,China)

机构地区：[1]辽宁省抚顺市传染病医院一疗区,辽宁抚顺113015 [2]辽宁省抚顺市传染病医院六疗区,辽宁抚顺113015

出　　处：《当代医学》2021年第1期28-30,共3页Contemporary Medicine

摘　　要：目的分析复合辅酶注射液治疗慢性乙型病毒性肝炎的临床效果。方法选取2013年1月至2018年12月于本院就诊的慢性乙型病毒性肝炎患者136例,采用随机数字表法分为对照组和观察组,每组68例。对照组采用恩替卡韦联合阿德福韦酯治疗,观察组采用恩替卡韦、阿德福韦酯联合复合辅酶注射液治疗。分析比较两组治疗效果。结果治疗后6个月,观察组IL-7水平高于对照组及治疗前(P<0.05);治疗后6个月,观察组HBV-DNA载量、ALT水平均低于对照组及治疗前(P<0.05);治疗后6个月,观察组ALT复常率、病毒学应答率、部分病毒学应答率高于对照组及治疗前(P<0.05);治疗后,观察组CLDQ评分高于对照组及治疗前(P<0.05);治疗后,观察组SF-36评分高于对照组及治疗前(P<0.05)。结论利用复合辅酶注射液治疗慢性乙型病毒性肝炎的临床效果显著,能提升生活质量,降低不良反应发生率。Objective To analyze the clinical effect of compound coenzyme injection on chronic viral hepatitis B.Methods 136 patients with chronic viral hepatitis B who were treated in our hospital from January 2013 to December 2018 were randomly divided into control group and observation group,with 68 cases in each group.The control group was treated with entecavir and adefovir dipivoxil,and the observation group was treated with entecavir and adefovir dipivoxil combined with compound coenzyme injection.The difference of therapeutic effect between two groups was analyzed.Results 6 months after treatment,the level of IL-7 in the observation group was higher than that in the control group and before treatment(P<0.05).6 months after treatment,the HBV-DNA load and ALT level in the observation group were lower than those in the control group and before treatment(P<0.05).6 months after treatment,the ALT normalization rate,virological response rate and some virological response rate in the observation group were higher than those in the control group and before treatment(P<0.05).After treatment,the CLDQ score in the observation group was higher than that in the control group and before treatment(P<0.05).After treatment,the SF-36 score in the observation group was higher than that in the control group and before treatment(P<0.05).Conclusion The use of compound coenzyme injection to treat chronic viral hepatitis has a significant clinical effect,which can improve the quality of life and reduce the risk of adverse reactions.

关 键 词：复合辅酶注射液 慢性乙型病毒性肝炎 临床效果 

分 类 号：R512.62[医药卫生—内科学]