芪蝎活血通络汤治疗脑梗死疗效及安全性分析  

Efficacy and safety analysis of Qixie Huoxue Tongluo Decoction in treating cerebral infarction

作　　者：王丽萍 潘燕君 刘晨萍[3] 刘登 张复亮 WANG Liping;PAN Yanjun;LIU Chenping;LIU Deng;ZHANG Fuliang(Department of General Practice of Traditional Chinese Medicine,Gucun Town Community Health Service Center,Baoshan District,Shanghai 201901,China;Department of Internal Medicine of TCM,Jing’an District Hospital of Traditional Chinese Medicine,Shanghai 200071,China;Department of Science and Education,Shanghai Hospital of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海市宝山区顾村镇社区卫生服务中心中医全科,上海201901 [2]上海市静安区中医医院中医内科,上海200071 [3]上海市中医医院科教科,上海200071

出　　处：《长春中医药大学学报》2020年第6期1211-1214,共4页Journal of Changchun University of Chinese Medicine

基　　金：上海市静安区科委中医专项资助项目(2018ZY02);上海市家庭医生中医药服务示范岗(Jtyszyfv28);上海市卫生计生委面上项目(201740271)。

摘　　要：目的探究芪蝎活血通络汤治疗气虚血瘀型脑梗死对患者肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平及神经功能的影响。方法选择200例气虚血瘀型脑梗死患者为研究对象,随机分为观察组和对照组,各100例。对照组予常规治疗,观察组在此基础上予芪蝎活血通络汤,2组均后续在医联体社区治疗2个月。比较2组治疗前后神经功能评分、血清炎症因子水平及治疗后临床疗效、治疗期间不良反应。结果观察组总有效率(92.00%,92/100)高于对照组(77.00%,77/100)(P<0.05)。治疗后,2组美国国立卫生研究院卒中量表(NIHSS)评分较治疗前降低,观察组低于对照组(P<0.05);2组日常生活活动能力(ADL)评分均较治疗前升高,观察组高于对照组(P<0.05);2组血清超敏C反应蛋白(hs-CRP)、TNF-α、IL-6水平均较治疗前降低,观察组低于对照组(P<0.05)。2组不良反应发生率无统计学差异(P>0.05)。结论芪蝎活血通络汤治疗气虚血瘀型脑梗死效果显著,可有效改善梗死部位供血供氧,减轻神经功能损伤,提高患者预后水平,且安全性较高。Objective To explore the therapeutic effcet of Qixie Huoxue Tongluo Decoction on the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and neurological function in patients with cerebral infarction of syndrome of qi deficiency and blood stasis type.Methods A total of 200 patients with cerebral infarction of syndrome of qi deficiency and blood stasis type were randomly divided into observation group(100 cases)and control group(100 cases).The control group was given routine treatment,and the observation group was given Qixie Huoxue Tongluo Decoction on this basis.Both groups were treated for 2 months.The score of neurological function,the level of serum inflammatory factor before and after treatment,clinical efficacy after treatment and adverse reactions during treatment were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group(92.00%vs.77.00%,P<0.05).After treatment,the score of national institute of health stroke scale(NIHSS)in the two groups was lower than that before treatment,and that in the observation group was lower than that in the control group(P<0.05).The score of activity of daily living(ADL)in the two groups was higher than before treatment,and that in the observation group was higher than that in the control group(P<0.05).The levels of serum high sensitivity C-reactive protein(hs-CRP),TNF-α,IL-6 in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Qixie Huoxue Tongluo Decoction has a significant effect in treating cerebral infarction of syndrome of qi deficiency and blood stasis type.It can effectively improve the blood supply and oxygen supply at the infarction site,reduce neurological function injury,improve the prognosis level of patients,and has high safety.

关 键 词：气虚血瘀型脑梗死 芪蝎活血通络汤 损伤性炎症 神经功能 

分 类 号：R255.2[医药卫生—中医内科学]